高原脱适应人群肝肾功能监测及结果分析  

Analysis of liver and renal function of immigrants deadaptated from high altitude

作　　者：项贵明[1] 王公权 张仕运 时胜学 倪伟伟[1] 吴杰红[1] 刘琳琳[1] 周其全[3] 蒲晓允[1] 

机构地区：[1]第三军医大学新桥医院检验科,重庆400037 [2]空军33师,重庆401329 [3]第三军医大学高原军事医学系高原疾病学教研室,重庆400038

出　　处：《国际检验医学杂志》2012年第20期2512-2513,共2页International Journal of Laboratory Medicine

基　　金：国家科技支撑计划课题资助项目(2009BAI85B03)

摘　　要：目的了解移居高原低氧环境人群返回平原后肝肾功能的变化,探讨高原脱适应对健康人肝肾功能的影响。方法选择初次进入高原地区驻训7个月的健康官兵作为观察对象,分别于驻训结束后返回平原当日及1个月后进行尿常规分析和血清肝肾功能检测,比较两个时间点的结果差异。结果受检者脱适应当日,尿常规分析和血清肝肾功能均出现异常,其中以总胆红素增高(44.19%)、尿微量清蛋白异常(32.10%)、尿酸增高(26.74%)最为常见;返回平原1个月后尿常规各项检测指标均得到明显改善,但是丙氨酸氨基转移酶和尿酸反而出现升高(P<0.05)。结论高原低氧环境对健康人的肝肾功能有一定损伤,返回平原后部分个体不能自行恢复,其脱适应过程中需要一定的药物干预。Objective To investigate the change of immigrant＇s liver and renal function deadaptated from high altitude and study the influence of liver and renal function by high altitude deadaptation. Methods To detect urine routine analysis and livcr, renal function of healthy soldiers immediately after they had been in high altitude for 7 months and compare the result to which of detec ted 1 month later. Results On the day of return T-BIL,mALB-U and UA increased most frequently, the increasing rale in immi-grants deadaptated from high altitude were 44.19 %, 32.10 % and 26.74 %respectively. After 1 month deadaptation the resuh of u rine routine analysis were improved obviously but ALT and UA were increased on the contrary（P〈0.05）. Conclusion Under the high altitude hypoxia circumstance the liver and renal function damage would emerge in healthy immigrants. Some of them shouldn＇ t recover by themselves and medicine intervention was required for their high altitude deadaptation accordingly.

关 键 词：高原脱适应 尿蛋白 谷丙转氨酶 尿酸 

分 类 号：R594.3[医药卫生—内科学]