先心病患者不同部位血浆心钠素水平及其与血浆cGMP、PRA的关系  

THE PLASMA ANF LEVELS AND THEIR RELATIONSHIP WITH cGMP, PRA, AND AT-Ⅱ

作　　者：李锡明[1] 李彦三 涂源淑[2] 冯义柏[2] 

机构地区：[1]蚌埠医学院附院内科 [2]同济医科大学心研所

出　　处：《蚌埠医学院学报》1991年第4期253-255,共3页Journal of Bengbu Medical College

摘　　要：对33例行右心导管术的先天性心脏病患者用放射免疫法测定了心脏不同部位的血浆心钠素(plasma atrial natriuretic factor, PANF)水平以及血浆肾素活性(plasma renin activity, PRA),血管紧张索Ⅱ(angiotensin Ⅱ,AT-Ⅱ),环磷酸鸟苷(cyclic guanosine monophosphate, cGMP),环磷酸腺昔(cyclic adenosine monophosphate, cAMP)浓度。结果肺动脉处PANF水平最高,PANF经肺循环后浓度降低;PANF与cGMP呈显著正相关;与PRA呈负相关。The plasma ANF level in blood samples withdrawn from different positions of central circulation, PRA , PAT-Ⅱ and cGMP were determined by radioimmuno assay in 33 patients with congerital heart disease undergoing right heart catheterization. The highest plasma ANF level was found in association with the pulmonary artery. There was a significant decrease in ANF concentration through pulmonary circulation. The plasma ANF concentrations were well correlated with plasma cGMP concentrations and negatively with PRA.

关 键 词：先天性心脏病 心钠素 血浆 

分 类 号：R541.102[医药卫生—心血管疾病]