乌鲁木齐地区妊娠中期妇女唐氏筛查血清标记物水平分析及研究  

The study on the maternal serum marker in second trimester prenatal screening for Down's syndrome in Urumqi

作　　者：王铮[1] 杨柳[1] 桂俊豪[1] 刘鸿春[1] 黄国香[1] 杨曦[1] 余伍忠[1] 陈石[2] 周瑾[2] 

机构地区：[1]兰州军区乌鲁木齐总医院临床医学研究所,新疆乌鲁木齐830000 [2]兰州军区乌鲁木齐总医院妇产科,新疆乌鲁木齐830000

出　　处：《国际检验医学杂志》2012年第21期2612-2613,2615,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨在唐氏筛查时对孕妇血清中甲胎蛋白(AFP)、游离β绒毛膜促性腺激素(F-βHCG)和游离雌三醇(uE3)参数评估时的实用意义。方法根据2009～2011年就诊的孕妇各孕周AFP、F-βHCG、uE3中位数,计算出AFP、F-βHCG、uE3的MOM值并进行风险评估,分析体重分组及孕龄分组时血清学的变化。结果正常母血中的AFP与F-βHCG标记物水平与母亲体重成负相关(P<0.01),另外血清AFP、uE3水平中位数与孕周呈正相关(P<0.01),而孕妇血清F-βhCG水平与孕周呈负相关(P<0.01)。本地区孕中期妇女的AFP平均水平比软件内嵌参数源人群(欧洲白人)AFP平均水平要高出10%,游离F-βHCG要高出10%,uE3高出12%,经过软件校正后的血清标记物MoM值均接近1。结论孕中期高水平血清学标记物与唐氏综合征(DS)患儿相关,经过分析得出新疆地区人群的血清指标与软件内嵌的参数源人群的血清平均水平接近,应用内嵌软件校正后能够有效的筛查出本地区的DS患儿。Abstract：Objective To study the clinical value of screening Down＇s syndrome by malernal serum markers with alpha fetal pro tein（AFP） , free chorionic gonadotropin beta subunit（F-βHCG）, unconjugated oestriol （uE3） in mid-pregnancy. Methods Serum AFP, F-βHCG and uE3 were detected in pregnant women of 14-- 20 weeks from 2009 to 20l 1, then the specific median and the cal culated MoM values were used to screen Down＇s syndrome among the pregnant women. The cases were divided into groups accord ing to the age and weight of the prenatal screening people, serum markers including AFP, F-βHCG and uE3 were analysed. Results The average level of serum AFP and F-βHCG has a significant negative correlation with weight （P〈0.01）. The gestational age is highly positive correlated with the level of serum AFP and uE3 （P〈0.01）, and highly negative correlated with lhe level of serum F-βHCG（P〈0.01）. Before the adjustment by weight,the average level of AFP,F-βHCG and uE3 in Urumqi increased 10%, 10 % and 12% than those of pregnant women in European respectively. After software correction the serum markers＇ MOM value were all close to 1. Conclusion The high level serum markers in the second trimester are related to Down＇s syndrome. There was no difference of corrected MoM levels between the crowd in Xinjiang and European in MultiCalc software. Adjusting MoM values of local populations can screen out the local fetuses with Down＇s syndrome more effectively.

关 键 词：唐氏综合征 产前诊断 甲胎蛋白类 Β-人绒毛膜促性腺激素 游离雌三醇 

分 类 号：R714.5[医药卫生—妇产科学]