不同性别冠心病患者冠状动脉病变的空间分布与血液流变学关系的研究  

The space distribution of coronary artery disease and hemorheology in female patients with coronary heart disease

作　　者：阚静[1,2] 陈绍良[1] 林玲[1] 徐海梅[1] 赵莹莹[1] 刘彦[1] 陈峰[2] 

机构地区：[1]南京医科大学附属南京市第一医院心内科,江苏南京210006 [2]南京医科大学公共卫生学院,江苏南京210006

出　　处：《国际检验医学杂志》2012年第21期2618-2620,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨女性和男性冠状动脉病变分布与血脂和血黏度变化的关系是否存在差异。方法选择2009年3月至2010年12月接受冠状动脉造影(CAG)的冠心病患者,其中2228例首发冠状动脉狭窄大于或等于50%的患者纳入分析,514例在CAG前完成血液流变检测。用ZL9000PLUS型血流变测定仪测定全血黏度(高切、中切、低切)、血浆黏度、血细胞比容(HCT)、红细胞聚集指数(EAI)、红细胞变形指数(EDI)、红细胞电泳时间。结果男性组不稳定性心绞痛和急性ST段抬高心肌梗死发病率高于女性(P<0.001),女性组全血低切还原黏度低于男性组(P<0.001),EAI低于男性组(P=0.002<0.05)。结论全血低切还原黏度和红细胞聚集指数增高为急性心肌梗死,血栓性病变的危险因素。Objective To explore the relationship between coronary artery disease distribution and blood viscosity in women and men. Methods Of 2 228 consecutive patients with coronary artery stenosis diagnosed by coronary artery angiography from May 2009 to December 2010, 514 patients measured blood viscosity before CAG were included. The hemorheology was measured with hemorrheology tester （ZL9000 PLUS）,including whole blood viscosity （high cut,cut,low cut）, plasma viscosity, red blood cell de- posited,erythrocyte deformation index, red cell aggregation index,and red blood cells electrophoretic time. Results Compared with women group,higher incidence in men group had unstable angina and acute ST-elevation myocardial infarction （68.3% vs 58.30/00, P〈0. 001 ;21.9% vs 13.4% ,P〈0. 001） ,and had more whole blood viscosity and red cell aggregation index [（40.70±3.27） vs （38.16±3.76） ,P〈0. 001 ;（4.61±0.39） vs （4.49±0.36） ,P=0. 002〈0.05]. Conclusion The increased of whole blood viscosi- ty and red blood cells gathered index would been risk factors in acute myocardial infarction and thrombosis lesions.

关 键 词：血液黏度 冠心病 女性 

分 类 号：R541.4[医药卫生—心血管疾病]