银杏叶提取物及银杏总内酯对帕金森病大鼠模型的作用  

The effects Ginkgo biloba extract and bilobalide on models of rat with Parkinson's disease

作　　者：郜文[1] 王丽娟[1] 景朋[1] 姚娴[1] 金有豫[1] 鲁厚桢[2] 

机构地区：[1]首都医科大学药物研究所,北京100054 [2]首都医科大学解剖教研室,北京100054

出　　处：《中国新药杂志》2000年第7期458-461,共4页Chinese Journal of New Drugs

摘　　要：目的 :研究银杏叶提取物、银杏总内酯对帕金森病 (PD)大鼠模型的作用。方法 :采用腹腔注射毒扁豆碱引起的急性震颤模型A以及单侧黑质注射微量 6 羟多巴胺造成的慢性旋转模型B ,观察银杏叶提取物、银杏总内酯的预防和治疗作用。结果 :银杏叶提取物 (10 0mg/kg)、银杏总内酯 (12mg/kg)在预防给药 14d后能够明显缩短模型A的震颤时间 ;在给药治疗 14d后能减轻模型B的旋转行为 ,而且银杏总内酯 (12mg/kg)还能使模型B受损侧纹状体的多巴胺含量升高。结论 :银杏叶提取物。Objective:To study the effects of Ginkgo biloba extract(GBE)and bilobalide on models of rat with Parkinson's disease.Methods:Models A and B were created respectively by ip injection of physostigmine and by injecting subtle 6 hydroxy dopamine into unilateral substantial nigra and observe the preservative and therapeutic effects of GBE and bilobalide.Results:After pre administration of GBE(100mg/kg)and bilobalide(12mg/kg)for 14d,the trembling time in model A was obviously shortened and after treatment for 14d,the rotational behavior in model B was decreased.The dopamine content in the damaged lateral striatum can be enhanced by bilobalide.Conclusion:GBE and bilobalide may be effective in prevention and treatment of Parkinson's disease.

关 键 词：银杏叶提取物 银杏总内酯 帕金森症 多巴胺 

分 类 号：R282.710.5[医药卫生—中药学] R277.725[医药卫生—中医学]