封闭抗体与不良妊娠的相关性研究  

Correlation research on blocking antibodies and adverse pregnancy

作　　者：张劲丰[1] 苏荣[1] 庄健海[1] 吴英[1] 安宏亮[1] 庞俏茹[1] 吴丹[1] 何娴[1] 简少珍[1] 杨延斌[1] 

机构地区：[1]佛山市中医院检验科,广东佛山528000

出　　处：《国际检验医学杂志》2012年第24期2949-2950,共2页International Journal of Laboratory Medicine

基　　金：广东省医学科研基金资助项目(A2010605)

摘　　要：目的探讨封闭抗体(BA)在早初孕和不良妊娠妇女人群中的分布情况及其相关性研究。方法收集该院妇科460例正常早初孕和不良妊娠病例,分为健康早初孕组212例(对照组)和不良妊娠组248例[包括不明原因复发性自然流产(UR-SA)、继发性不孕、偶发性自然流产3组]。采用ELISA法检测各病例组血清中的BA。结果各组BA阳性率分别为对照组50.9%(108/212),URSA组26.8%(22/82),继发不孕组42.9%(48/112),偶发性自然流产组70.4%(38/54)。各组BA阳性率及总体之间比较差异有统计学意义(P<0.05);对照组与URSA组比较差异有统计学意义(P<0.05),与偶发性自然流产组和继发性不孕组比较差异无统计学意义(P>0.05)。结论 BA缺失和URSA发生有关,与继发性不孕和偶发性自然流产无明显相关。Objective To investigate blocking antibodies in early first pregnancy and adverse pregnancy women population distributions and correlation research.Methods To collected 460 early pregnancy and adverse pregnancy cases from Gynecology in Foshan-TCM hospital which included 212 cases of early pregnancy first time as the control group,and the 248 adverse pregnancy cases incloude unexplained recurrent spontaneous abortion（URSA） group,secondary infertility group and occasional spontaneous abortion group.The block antibody（BA） was tested by ELISA.Results The positive rates of BA in early pregnancy first time group,URSA group,and secondary infertility group,occasional spontaneous abortion group respectively were：50.9%（108/212）,26.8%（22/82）,42.9%（48/112）,70.4%（38/54）.The overall difference in positive rates of BA of four groups were significant（P0.05）.The difference in positive rate of BA of early pregnancy first time group and URSA group was significant（P0.05）,and no significant difference to sporadic abortion group and secondary infertility group（P0.05）.Conclusion Deletion of BA was relevant to the occurrence of URSA,which had no significant correlation with secondary infertility and sporadic spontaneous abortion.

关 键 词：抗体 封闭 流产 自然 妊娠结局 不育 女(雌)性 

分 类 号：R714.21[医药卫生—妇产科学]