二氟尼柳治疗类风湿性关节炎和退行性骨关节炎的临床研究  

A randomized and controlled clinical study of diflunisal in treatment of rheumatoid arthritis and degenerative osteoarthritis

作　　者：谷卫[1] 宋作圭[1] 

机构地区：[1]浙江大学医学院附属第二医院内分泌科,杭州310009

出　　处：《中国新药杂志》2000年第7期491-493,共3页Chinese Journal of New Drugs

摘　　要：目的 :评价二氟尼柳治疗类风湿性关节炎和退行性骨关节炎的临床疗效和安全性。方法 :采用随机对照试验 ,选用布洛芬作为对照药。试验组共 94例 ,其中类风湿性关节炎 5 5例 ,退行性骨关节炎 39例。对照组共5 8例 ,其中类风湿性关节炎 37例 ,退行性骨关节炎 2 1例。结果 :试验组和对照组治疗类风湿性关节炎和退行性骨关节炎均有效 ,但二氟尼柳的疗效略优于布洛芬 ,治疗类风湿性关节炎总有效率分别为 87.2 7%和 86 .49% ,退行性骨关节炎总有效率分别为 94.87%和 76 .19%。试验组和对照组的不良反应发生率分别为 30 .85 %和 39.6 6 %。结论 :二氟尼柳疗效好 ,不良反应少 ,应用方便 。Objective:To evaluate the efficacy and safety of diflunisal in treatment of rheumatoid arthritis and degenerative osteoarthritis.Methods:The study was conducted in 152 patients with rheumatoid arthritis (92 patients)or degenerative osteoarthritis (60 patients).They were randomly divided to receive diflunisal or ibuprofen.In rheumatoid arthritis group,there are 55 patients in active arm and 37 in control arm.In the degenerative osteoarthritis group,there are 39 patients in active arm and 21 in control arm.Results:Both diflunisal and ibuprofen were effective in treatment of rheumatoid arthritis and degenerative osteoarthritis but the efficacy of diflunisal was superior to that of ibuprofen.The effective rate in treatment of rheumatic arthritis for diflunisal and ibuprofen were 87.27% and 86.49% and that in treatment of degenerative osteoarthritis for diflunisal and ibuprofen were 94.87% and 76.19% respectively.The adverse events were 30.85% for diflunisal and 39.66% for ibuprofen respectively.Conclusion:Diflunisal is an effective and convenient agent for treatment of both rheumatoid arthritis and degenerative osteoarthritis with mild side effects.

关 键 词：类风湿性关节炎 退行性骨关节炎 二氟尼柳 

分 类 号：R593.220.5[医药卫生—内科学]