Influence of Tanshinone lla on heat shock protein 70,Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury  

作　　者：Li Zhang Weidong Gan Guoyao An 

机构地区：[1]School of Traumatology and Orthopedics,Fujian University of Traditional Chinese Medicine

出　　处：《Neural Regeneration Research》2012年第36期2882-2888,共7页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.30973765;New Century Excellent Talents Program,No. NECT-09-0013;the Foundationfor Doctors,Ministry of Education,No.20113519110001

摘　　要：Tanshinone lla is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone Ila can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone lla, 0.5 hour prior to model establishment. Results showed that Tanshinone Ila promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone Ila, compared with positive control Danshen injection.Tanshinone lla is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone Ila can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone lla, 0.5 hour prior to model establishment. Results showed that Tanshinone Ila promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone Ila, compared with positive control Danshen injection.

关 键 词：Tanshinone Ila DANSHEN spinal ischemia/reperfusion injury heat shock protein 70 BCL-2 BAX cellapoptosis Chinese medicine neural regeneration 

分 类 号：R285.5[医药卫生—中药学]