生物性材料硫酸钙作为复合材料的应用研究与进展  

Calcium sulfate: A new application as a mixture with other bone graft materials

作　　者：王玉路[1] 潘志军[2] 杨增华[1] 

机构地区：[1]包头医学院第一附属医院骨三科,内蒙古自治区包头市014010 [2]浙江大学医学院附属第二医院骨科,浙江省杭州市310009

出　　处：《中国组织工程研究》2012年第51期9624-9628,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:将硫酸钙与其他生物材料混合可以克服硫酸钙本身的缺点。目的:探讨生物性材料硫酸钙作为复合材料在局部药物释放载体及骨生物材料应用方面的性能。方法:以"硫酸钙,骨修复材料,缓释系统,生物学材料,复合材料"为中文关键词,以"Calcium sulfate,Mixture,Bone defect,Drug release"为英文关键词,采用计算机检索万方数据库、PubMed数据库等1980年1月至2012年3月有关硫酸钙作为复合材料在局部药物释放载体及骨生物材料中应用的文章。结果与结论:硫酸钙作为骨缺损修复材料具有很多优点,但吸收快、缓释药物慢等缺点限制了其应用。因此对硫酸钙作为复合材料的研究开始增多,无论是作为药物释放载体还是作为骨替代材料,硫酸钙与其他材料混合发挥了复合材料的互补特性,很大程度上满足了生物材料应具有的综合特点。这样既保留了硫酸钙的成骨和骨诱导等优点,又克服了其不足。但关于这方面研究仍处于起步阶段,复合材料的配比、体内特性、临床应用等仍需进一步研究。BACKGROUND：Calcium sulfate is mixed with other biomaterials in order to overcome its weaknesses or failings. OBJECTIVE：To investigate the application of calcium sulfate as a mixture with other materials acting as drug release system and scaffold material for tissue engineering. METHODS：Using ＂calcium sulfate, bone repair material, drug release, biomaterials, compound materials＂ in Chinese and ＂calcium sulfate, mixture, bone defect, drug release＂ in English as the key words, a computer-based online search of China Academic Journal Full-text database and PubMed database （1980-01/2012-03） was performed for articles about the application of calcium sulfate as a mixture with other materials. RESULTS AND CONCLUSION：Calcium sulfate has more advantages and peculiarities than other biomaterials and make a well development in clinic. However, some disadvantages such as too rapid resorption or too short drug release period hinder its widespread use in clinic. Therefore, many studies have been focused on the application of calcium sulfate as a mixture with other materials recently. Combining calcium sulfate with other material to obtain an ideal material may be a promising and sane choice. This can make the best use of calcium sulfate advantages and bypass its disadvantages. Future research is required to enhance and improve the resorption property, drug release profile, handling characteristics and physical properties of calcium sulfate through mixing with other materials while preserving its biocompatibility and osteoconduction.

关 键 词：硫酸钙 骨修复材料 缓释系统 生物学材料 复合材料 

分 类 号：R318[医药卫生—生物医学工程]