磷酸钙骨水泥的生物学特征及其作用  

Biological characteristics and effect of calcium phosphate bone cement

作　　者：唐正海[1,2] 王晓文[1] 唐劲天[1] 

机构地区：[1]清华大学玉泉医院脑神经疾病研究所,北京市100049 [2]北京中医药大学生物制药系,北京市100102

出　　处：《中国组织工程研究》2012年第51期9640-9644,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81071885)~~

摘　　要：背景:传统磷酸钙水泥存在力学强度差、注射性低和固化时间长等缺点,限制了其在临床上的应用。目的:回顾分子磷酸钙水泥性能的改善方法及临床应用。方法:通过检索Web of knowledge平台(1995至2011年)和中国期刊全文数据库(1995至2011年)有关磷酸钙水泥性能改善以及应用等方面相关文献,最终纳入34篇符合标准的文献进行综述。结果与结论:磷酸钙水泥具有良好的生物相容性,孔隙率,可塑性,无毒等优点,被广泛应用于药物载体,骨修复材料,骨肿瘤治疗等领域。为克服传统的磷酸钙水泥力学强度差,凝固时间长,注射性差等问题,目前主要通过调节磷酸钙水泥的固相成分、颗粒大小、添加有机溶剂等方法来提高磷酸钙水泥性能。BACKGROUND：The mechanical strength, injectable ability and solidification of traditional calcium phosphate cement were too poor to develop its clinical application. OBJECTIVE：To review the methods to increase the properties of calcium phosphate cement and its clinical application. METHODS：An online search of Web of Knowledge and CNKI database was performed for articles addressing performance improvement and clinical application of calcium phosphate cement published between 1995 and 2011. Finally, 34 articles were selected in result analysis RESULTS AND CONCLUSION：Calcium phosphate cement is characterized as good biocompatibility, porosity, plasticity, and non-toxic, which has been widely used as drug carrier, bone repair materials as well as in the treatment of bone tumors. Nowadays, the performance of calcium phosphate cement is improved by regulating the solid-phase composition of calcium phosphate cement, particle size and adding organic solvent.

关 键 词：磷酸钙 骨水泥 骨修复 肿瘤 综述 

分 类 号：R318[医药卫生—生物医学工程]