非创伤性股骨头坏死患者血清瘦素与血脂水平正相关  

Positive correlation between serum leptin and lipid levels in patients with nontraumatic femoral head necrosis

作　　者：王辉[1,2] 李会杰[1,2] 郑越[1,2] 杨祥雷[1,2] 

机构地区：[1]河北医科大学第三医院骨病科 [2]河北省骨科研究所,河北省石家庄市050051

出　　处：《中国组织工程研究》2012年第52期9860-9866,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:由于瘦素与骨质疏松发病关系密切,因而可能与股骨头坏死的发病有关。目的:探讨血清瘦素和血脂水平与股骨头坏死发病的相关性。方法:选取2011年6月至2012年3月在河北医科大学第三医院骨病科住院的65例非创伤性股骨头坏死患者及60例健康对照者,检测2组血清瘦素、总胆固醇、三酰甘油、中低密度脂蛋白、高密度脂蛋白和载脂蛋白A1,B水平。结果与结论:股骨头坏死患者组血清瘦素、总胆固醇、三酰甘油、中低密度脂蛋白、载脂蛋白B水平均明显高于对照组(P<0.05),而血清高密度脂蛋白、载脂蛋白A水平较对照组明显降低(P<0.05)。股骨头坏死组与对照组女性血清瘦素水平均高于男性(P<0.05)。血清瘦素水平与血脂水平呈正相关。提示:①非创伤性股骨头坏死患者血清瘦素水平升高,可能在其发病过程中发挥一定作用。②非创伤性股骨头坏死的发生发展与血脂的变化有密切关系。BACKGROUND： As the leptin has close relationship with the incidence of osteoporosis, so it may relates to the incidence of femoral head necrosis. OBJECTIVE： To study the correlation between serum leptin, serum lipid and osteonecrosis of femoral head. METHODS： From June 2011 to March 2012, 65 patients with nontraumatic osteonecrosis of the femoral head were selected from Department of Orthopedics, the Third Hospital of Hebei Medical University, and 60 healthy adults were selected as controls. The levels of serum leptin, total cholesterol, triglyceride, low and medium-density lipoprotein, high-density lipoprotein and apolipoprotein A1 and B were measured. RESULTS AND CONCLUSION： In osteonecrosis of the femoral head group, the levels of serum leptin, total cholesterol, triglyceride, low and medium-density lipoprotein and apolipoprotein B were significantly higher than those in the control group （P 0.05）, while the levels of high-density lipoprotein and apolipoprotein A1 were significantly lower than those in the control group （P 0.05）. The level of serum leptin in the female patients was higher than that in the male patients （P 0.05）. The level of serum leptin was positively correlated with serum lipid. ①The increasing of the serum leptin level in patients with nontraumatic osteonecrosis of the femoral head plays a role in the process of the disease. ②The serum leptin concentrations are positively correlated with the development of nontraumatic osteonecrosis of the femoral head.

关 键 词：非创伤性股骨头缺血坏死 血清 瘦素 总胆固醇 三酰甘油 脂蛋白 骨代谢 血脂代谢 瘦素抵抗 组织工程 

分 类 号：R318[医药卫生—生物医学工程]