黄芪多糖对STZ糖尿病小鼠内皮祖细胞功能的作用  

Effects of astragalus polysaccharide on function of EPCs in STZ-induced diabetic mice

作　　者：张根水[1] 张贵平[1] 罗柳金[1] 

机构地区：[1]广州医学院药理学教研室,广州510182

出　　处：《中药药理与临床》2012年第6期77-79,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：广州医学院博士启动基金项目(No:2009-17)

摘　　要：目的:观察黄芪多糖对STZ诱导一型糖尿病小鼠骨髓内皮祖细胞(EPCs)功能的作用。方法:糖尿病小鼠给予100mg/kg与400 mg/kg黄芪多糖腹腔注射4周,观察小鼠EPCs小管形成能力、粘附能力以及VEGF蛋白表达。结果:黄芪多糖给药4周后,100 mg/kg与400 mg/kg两个剂量组EPCs小组形成与细胞粘附显著多于对照组(P<0.05),明显降低STZ糖尿病小鼠血糖水平(P<0.05),并能明显升高VEGF蛋白表达(P<0.05)。结论:黄芪多糖能改善糖尿病EPCs功能,可能有助于糖尿病伤口愈合的内皮修复。AIM： To study the effects of astragalus polysaccharide （APS） on function of endothelial progenitor cells （EPCs） in streptozotocin in- duced type I diabetic mice. Methods： The effects of APS with 100 and 400mg/kg intrapefitoneal injection were investigated by determination tube formation, adhesion of EPCs and VEGF protein expression. Results： Long-term administratiun with 100 and 400mg/kg APS significantly increased the tube formation, adhesion function and VEGF protein expression of EPCs compare to the control group besides the decreasing effects on blood glucose of STZ-induced diabetic mice （ P 〈 0.05 ）. Conclusion： These results suggest that chronic treatment with APS ex- perts an ameliorate effect on EPCs function in STZ-induced diabetic mice. The effects of APS suggest the application of APS in the wound healing of diabetes.

关 键 词：黄芪多糖 糖尿病 血管内皮生长因子 内皮祖细胞 

分 类 号：R285[医药卫生—中药学]