蜣螂抗良性前列腺增生症活性部位的筛选(Ⅰ)  

Screening of active fraction of anti-benign prostatic hyperplasia from Catharsisus molossus(Ⅰ)

作　　者：蒋巧梅[1,2] 谭承佳[3] 马家骅[1,4] 杨明[1] 

机构地区：[1]成都中医药大学,成都611137 [2]四川升和药业股份有限公司,成都611130 [3]绵阳师范学院,绵阳621000 [4]西南科技大学,绵阳621010

出　　处：《中药药理与临床》2012年第6期100-103,共4页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金项目(30902005);绵阳市科技计划项目(09S002-2)

摘　　要：目的:在本草学的指导下探讨蜣螂抗良性前列腺增生症的作用,筛选其活性部位。方法:采用丙酸睾酮致小鼠前列腺增生模型,以前列腺指数、小鼠前列腺病理组织学结果为评价指标,考察蜣螂不同提取部位对前列腺增生的作用,并采用大孔树脂吸附与透析技术对有效部位进行初步分离。结果:蜣螂乙醇提取总部位(20g生药/kg)、三氯甲烷萃取部位(20g生药/kg)、萃取剩余部位(20g生药/kg)能明显减小造模小鼠前列腺指数,降低腺体增生程度,所得有效部位多肽含量达83.6%。结论:蜣螂乙醇提取总部位、三氯甲烷萃取部位、萃取剩余部位具有明显抑制前列腺增生的作用,其抗前列腺增生的主要活性组分为多肽。To screen the active fraction and observe the effect of Catharsisus molossus Linnaeus on benign prostatic hyperplasia under the guidance of herbalism. Methods： Experimental prostatic hyperplasia was induced by testosterone propionate in mice, and took prostate index and histology under light microscope as evaluating indexes. Results： The prostate weight and prostate index were lowered, and patho- logical changes were significantly improved in mice treated with the ethanol extract （20g/kg）, chloroform extract （20g/kg） and residue of extract （20g/kg）. The effective fraction mainly contained 83.6% of the peptide. Conclusion： All the ethanol extract, chloroform extract and residue of extract from Catharsisus molossus Linnaeus can significantly inhibit experimental prostatic hyperplasia. Peptide was the main active component inhibiting benign prostatic hyperplasia.

关 键 词：蜣螂 良性前列腺增生症 活性部位 

分 类 号：R285[医药卫生—中药学] R284[医药卫生—中医学]