清开灵对自然衰老小鼠脑组织炎症因子及β-淀粉样蛋白水平的影响  

Effect of Qinkailing on inflammatory factors and the expression of β-amyloid protein of brain tissue in natural aging mice

作　　者：王永丽[1] 杨章群[1] 杨建坤[1] 

机构地区：[1]河北大学附属医院药剂科,保定071000

出　　处：《中药药理与临床》2012年第6期108-110,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：河北省科学技术研究与发展计划项目(10276105D-89)

摘　　要：目的:观察清开灵对自然衰老小鼠学习记忆能力及脑组织炎性因子、β-淀粉样蛋白水平的影响。方法:雄性自然衰老KM小鼠50只随机分成5组:空白对照组、清开灵20 g/kg组,清开灵40 g/kg,清开灵80 g/kg组和阳性对照药尼莫地平0.3 g/kg组。灌胃给予等体积药物或注射用水,每日给药1次,连续给药30d,观察小鼠学习记忆能力及脑组织炎症因子、β-淀粉样蛋白的含量。结果:清开灵能显著改善自然衰老小鼠学习记忆能力;明显降低脑组织IL-1、IL-6和TNF-α的含量及β-淀粉样蛋白水平。结论:清开灵可通过降低脑组织炎症因子的水平、减少脑组织β-淀粉样蛋白的生成,改善自然衰老小鼠的学习记忆能力。To study the effect of Qingkailing in natural aging mice by measuring learning and memory ability and some biochemical in- dexes in brain tissue. Methods： The Morris water maze was used to observe the learning and memory ability of natural aging mice. Biochemi- cal methods were used to determine the content of IL - 1, IL - 6, TNF - ct and Aβ in brain tissue. Results： （ 1 ） Qingkailing could significant- ly improve the memory of natural aging mice （2） Compared with the control group, Qingkailing could decrease the content of IL - 1, IL - 6, TNF - ct and Aβ in the brain tissue obviously . Conclusion： Qingkailing could improve the ability of learning and memory of natural aging mice, and its mechanism might involved in reducing the level of IL - 1 ,IL -6,TNF - a and Aβ in brain tissue.

关 键 词：清开灵 自然衰老小鼠 学习记忆 炎症因子 β-淀粉样蛋白 

分 类 号：R285[医药卫生—中药学]