艾叶烟气致慢性阻塞性肺疾病大鼠的研究  

Experimental study on Chinese mugwort leaves' smoke leading to chronic obstructive pulmonary disease

作　　者：赵玉雪[1] 于浩飞[1] 刘佳[2] 李进涛[1] 倪师今[3] 张荣平[1] 

机构地区：[1]昆明医科大学药学院,昆明650500 [2]昆明医科大学海源学院,昆明650101 [3]云南省肿瘤医院,昆明650118

出　　处：《中药药理与临床》2012年第6期141-144,共4页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:探讨艾叶烟气是否会导致SD大鼠慢性阻塞性肺疾病。方法:30只SD雄性大鼠随机分为空白组、艾条组、烟叶组,单纯熏烟下暴露三个月进行一般体征观察、病理学观察、血常规检测、BALF细胞学检测。结果:与空白组相比较,艾叶组(纯艾条24克/2次/日)和烟草组(红河香烟60克/2次/日)大鼠有明显慢性支气管炎特征性病理学改变,肺组织细胞损伤,管壁炎症细胞浸润,肺泡扩大融合,符合COPD形态学诊断指标;白细胞总数及中性粒细胞明显上升,有显著性差异(P<0.01);血清及BALF中的TNF-a、IL-8含量明显升高,具有统计学意义(P<0.01)。结论:艾叶能导致SD大鼠产生明显的慢性阻塞性肺疾病病变特点。Aim： To investigate whether the chinese mugwort leaves smoke will lead to Chronic Obstructive Pulmonary Disease. Method： Thirty male SD rats were randomly divided three groups： blank group, leaves group and cigarette group. SD rats were exposed to simple fume for three months. The general signs and pathological features were observed, and blood routine and BALF cytology were measured. Results： Compared with the blank group, the bronchia of leaves group （ pure moxa stick, 24g/2times/day） and cigarette group （ Hong he-cigarette 60g/2times/day） rats showed obviously chronic bronchitis characteristic pathological changes in lung tissue that the structure of pulmonary disorder, such as lung tissue cells damage, inflammatory cell infiltration and alveolar enlarged and fusion as lung buUae, in line with the mor- phology of COPD diagnosis; the number of leukocyte and neutrophils increased obviously （P 〈 0.01 ） ; the IL-8, TNF-a expression in BALF and serum inereasd significantly （P 〈 0.01 ）. Conclusion： The chinese mugwort leaves＇smoke can lead rats to Chronic Obstructive Pulmona- ry Disease.

关 键 词：艾叶 烟气 肺疾病 慢性阻塞性 大鼠 

分 类 号：R259[医药卫生—中西医结合]