天然植物雌激素-染料木黄酮延缓女性更年期的临床疗效观察及其作用机制的研究  

Observation on clinical effect of natural phytoestrogens-genistein for delaying female menopause and its mechanism

作　　者：李亚玲[1] 叶云[1] 李俊[1] 

机构地区：[1]泸州医学院附属医院药剂科,四川泸州646000

出　　处：《中国妇幼保健》2013年第4期645-649,共5页Maternal and Child Health Care of China

摘　　要：目的:观察染料木黄酮(GST)延缓女性更年期的临床疗效和安全性,探讨其作用机制。方法:将选择好的受试者随机分为GST、ISO组和安慰剂对照组,各组按规定服用试验胶囊,试验前后进行改良Kapperman评分和各项指标检测,统计更年期相关疾病发生率,所得数据进行多元逐步回归及方差分析比较。结果:GST、ISO组的临床症状较试验前有显著改善(P<0.01)和有所改善(P<0.05),性激素基本恢复到正常水平和有所恢复,两组均无明显不良反应;安慰剂组的临床症状较试验前更加严重,激素更加偏离正常水平,相关疾病发生率>GST和ISO组。结论:GST能延缓更年期,可减少相关疾病的发生率,疗效确切、安全,其延缓更年期的机制可能与其雌激素效应有关。Objective： To observe the clinical effect and safety of genistein （GST） for delaying female menopause, and explore the mechanism. Methods： The study objects were randomly divided into GST group, ISO group, and placebo group, the objects in the three groups were treated with oral administration of experimental capsules, improved Kapperman scores and detections of various indexes were conducted before and after treatment, the incidence rate of menopause - related diseases was analyzed statistically, then the data were ana- lyzed and compared by multivariate stepwise regression analysis and variance analysis. Results： The clinical symptoms in GST group and ISO group improved significantly after treatment, respectively （P 〈 0. 01 ） （P 〈 0. 05） ; the levels of sex hormones basically returned to nor- mal levels, no obvious adverse reactions occurred in the two groups ; the clinical symptoms after treatment in placebo group became severer, and the levels of hormones deviated from normal levels, the incidence rate of menopause - related diseases in placebo group was higher than those in GST group and ISO group. Conclusion： GST can delay menopause and reduce the incidence rate of menopause - related diseases, and it is effective and safe, the mechanism is related to their estrogen effect.

关 键 词：染料木黄酮 延缓更年期 临床观察 作用机制 

分 类 号：R711.75[医药卫生—妇产科学]