母亲还原叶酸载体1基因80G／A多态性与子女唐氏综合症易感性关系的meta分析  

Correlation between maternal reduced folate carrier 1 gene 80G/A polymorphism and offspring down syndrome susceptibility: A meta-Analysis

作　　者：何大莉[1] 曾照芳[1] 

机构地区：[1]重庆医科大学检验医学院,临床检验诊断学教育部重点实验室,重庆市重点实验室,重庆400016

出　　处：《激光杂志》2013年第1期80-82,共3页Laser Journal

摘　　要：目的:探讨母亲还原叶酸载体1(RFC1)基因80G/A多态性与子女唐氏综合症(DS)易感性的相关性。方法:计算机检索PubMed、MEDLINE、Web ofScience、CNKI、CBM数据库,收集从建库至2012年9月间关于母亲RFC1基因80G/A多态性与子女DS易感性相关性的病例对照研究,对符合纳入标准的文献进行Meta分析。结果:共纳入7个研究,包括病例625例,对照767例。Meta分析结果显示:母亲RFC1基因80G/A多态性与子女DS易感性的相关性在各比较模型中差异无统计学意义〔A Vs.G:OR=0.85,95%CI(0.73,1.00);AA Vs.GG:OR=0.73,95%CI(0.53,0.99);AA Vs.AG+GG:OR=0.82,95%CI(0.63,1.06);AA+AG Vs.GG:OR=0.81,95%CI(0.64,1.03)〕。基于人种的亚组分析结果显示,两者相关性无统计学意义。结论:目前的研究结果显示,母亲RFC1基因80G/A多态性与子女DS易感性无明显相关性。Objective： To evaluate the correlation between nmtemal reduced folate cartier 1 （RFCl）gene 80G/A polynlorphism and offspring Down syndrome susceptibility. Methods：We searched PubMed, MEDLINE, Web of Science, CNKI, CBM database and collected all the publications about the correlation between maternal reduced folate carrier 1 gene 80G/A polymorphism and offspring Down syndrome susceptibility. Results： A total of 7 studies involving 625 mothers who had children affected by DS and 767 controls mothers who had no miscarriages or children affected by genetic disorders in their life. The results of meta - analyses showed no significant difference was found in the correlation between maternal RFC1 80G/A polymorphism and offspring Down syndrmne susceptibilityl A Vs. G： OR=0.85,95%CI（0.73,1.00}; AA Vs. GG： OR=0.73,95%CI（0.53,0.99）; AA Vs. AG＋ GG： OR=0.82,95%CI（0.63,1.06）; AA＋ AG Vs. GG： OR = 0.81,95 % CI { 0.64,1.03 ） . In the subgroup analyses on ethnicity, no significant correlation was found. Conclusion： The present meta - analysis suggests that the correlation between maternal RFCI 80G/A polymhism and offsprin Down syndrome susceptibility is not sitmificantly different.

关 键 词：唐氏综合症 21三体综合症 还原叶酸载体1 80G A 基因多态性 META分析 

分 类 号：TN248.1[电子电信—物理电子学]