基于防突变浓度的新型药动学-药效学-突变选择窗同步模型在临床用药上的指导作用  

Instruction Function in Drug Administration on the New PK-PD-MSW Modeling Based on Mutant Prevent Concentration

作　　者：廖雪玲 张炳旭[2] 丁焕中[2] 

机构地区：[1]上海公谊兽药厂,上海201401 [2]华南农业大学兽医学院,广东广州510642

出　　处：《中国畜牧兽医》2013年第1期199-203,共5页China Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金资助项目(31172366)

摘　　要：文章综述了抗菌药药动学/药效学(PK/PD)模型的发展,详细阐述新型药动物学/药效学模型在抑制细菌耐药突变上的作用,为合理用药及新药研发提供指导,并指出了临床应用所存在的问题。Development history of pharmacokinetic/pharmacodynamic（PK/PD） model for antimicrobial drugs was reviewed in the present article,including the important role of new PK/PD model in inhibition bacterial resistance mutation,intruction in the rational design of drug regimen and new drug investigation.In addition,problems of clinical application of PK/PD model were also discussed.

关 键 词：药动学 药效学模型 突变选择窗 耐药性 合理用药 

分 类 号：S859[农业科学—临床兽医学]