参附芎泽胶囊治疗慢性心力衰竭59例临床观察  

Clinical Observation on Shenfu Xiongze Capsule for 59 Cases of Chronic Heart Failure

作　　者：王永刚[1,2] 钟伟[1,2] 于远望[1] 李军[1,3] 郑刚[1,2] 张学文[1,3] 王礼凤[1,2] 尚俊平[1,2] 齐婧[1,2] 

机构地区：[1]陕西中医学院心脑血管病研究所,陕西省咸阳市渭阳西路5号712000 [2]陕西中医学院第二附属医院 [3]陕西中医学院张学文国医大师研究所

出　　处：《中医杂志》2013年第3期218-221,共4页Journal of Traditional Chinese Medicine

基　　金："十一五"国家科技支撑计划项目(2006BAI08B02-01);国家自然科学基金资助项目(30973830;30901895);陕西省社会发展攻关项目(2010K17-01);陕西省教育厅科学研究计划资助项目(11JK0690)

摘　　要：目的观察参附芎泽胶囊治疗慢性心力衰竭(CHF)患者的临床疗效。方法将120例CHF患者随机分为对照组和治疗组各60例。两组均采用规范的西医内科基础治疗方案,治疗组给予参附芎泽胶囊,对照组给予参附芎泽胶囊安慰剂,两组均每次1.2g,每日3次,治疗6个月。观察两组患者治疗前后血浆脑利钠肽(BNP)、心功能分级、6分钟步行试验、中医证候积分和明尼苏达生活质量评分。结果与治疗前比较,两组患者治疗后BNP、心功能分级、6分钟步行试验、中医证候积分、明尼苏达生活质量评分均有改善(P<0.05或P<0.01);治疗后各指标治疗组较对照组改善程度更为显著(P<0.05或P<0.01)。结论参附芎泽胶囊治疗CHF具有一定的临床疗效。Objective To observe the therapeutic effect of Shenfu Xiongze Capsule [capsule of Renshen （Radix et Rhizoma Ginseng）, Fuzi （Radix Aconiti Lateralis Praeparata ） , Chuanxiong （Rhizoma Chuanxiong ） and Zexie （Rhizoma Alisrnatis） ] on chronic heart failure （CHF）. Methods Totally 120 CHF patients were randomized into treatment group and control group, with 60 in each. Both groups were given ordinary basic treatment. Additionally, the treatment group was given Shenfu Xiongze Capsule and the control group was given placebo, 1.2 g once, 3 times each day. The treatment lasted for 6 months. The plasma brain natriuretic peptide （BNP）, cardiac function classification, six-minute walk test （6MWT）, Chinese medicine syndrome in- tegral and Minnesota quality of life scale were observed. Results The BNP, cardiac function classification, 6MWT, Chinese medicine syndrome integral and Minnesota quality of life scores were significantly improved in both groups after treatment （P〈 0.05 or P〈0.01）, especially in the treatment group （P〈0. 05 or P〈0. 01）. Conlcusion Shenfu Xiongze Capsule is effective for CHF.

关 键 词：慢性心力衰竭 参附芎泽胶囊 心功能分级 6分钟步行试验 

分 类 号：R541.6[医药卫生—心血管疾病]