芪参复康胶囊对首发抑郁症患者记忆功能及事件相关电位的影响  

Memory function and event-related potentials change in first-episode depressions treated with Qishen Fukang capsules

作　　者：陈玖[1] 杨来启[1] 吴兴曲[1] 李新田[1] 林昱[1] 张彦[1] 邱财荣[1] 

机构地区：[1]中国人民解放军第三医院全军精神疾病防治中心,陕西宝鸡721004

出　　处：《中国医院药学杂志》2013年第3期221-224,共4页Chinese Journal of Hospital Pharmacy

基　　金：军队中医药科研专项课题(编号:10ZYX108)

摘　　要：目的:探讨首发抑郁症患者应用中药芪参复康胶囊治疗前后的记忆功能、事件相关电位(Event-related potential,ERP)指标的变化。方法:将70例首发抑郁症患者按随机数字表法分成2组,中药组(35例)给予芪参复康胶囊0.2～0.6g口服,每天3次,西药组(35例)给予用氟西汀胶囊(江苏常州制药有限公司)20～40(20±5)mg.d-1,每日晨口服,可酌情短期合用小剂量苯二氮芯卓类药,不合用其他抗抑郁药。2组患者于治疗前、治疗后12周进行24项HAMD、韦氏记忆评定及行P300检查,34名健康志愿者(对照组)行P300检查。分析2组患者治疗前后对记忆功能的影响。结果:(1)治疗第12周后患者组的HAMD总分显著下降[中药组(30.1±6.2)分vs(11.1±3.2)分;西药组(29.4±5.4)分vs(13.3±3.4)分];中药组HAMD减分率显著高于西药组[(63.1±4.6)%vs(55.1±4.1)%,P<0.05]。(2)与治疗前相比,2组治疗后长时记忆、短时记忆和瞬时记忆评分均显著升高,记忆商显著升高(P<0.05);与对照组相比,短时记忆和瞬时记忆治疗后中药组差异不显著(P>0.05),西药组仍显著偏低(P<0.05)。(3)与治疗前相比,2组治疗后P3潜伏期均显著缩短[中药组:(378.4±35.8)msvs(322.2±20.6)ms;西药组:(376.8±38.1)ms vs(316.8±41.3)ms,P<0.01]、波幅均显著升高[中药组:(3.3±1.4)μVvs(9.0±2.2)μV;西药组:(3.4±1.2)μVvs(8.4±1.6)μV,P<0.01]。与对照组相比,2组治疗前潜伏期显著延迟、波幅均显著降低(P<0.01),治疗后P3潜伏期均差异不显著、中药组P3波幅差异不显著(P>0.05),西药组P3波幅仍显著降低(P<0.05)。结论:首发抑郁症患者接受芪参复康胶囊和氟西汀治疗12周后临床症状明显缓解、认知功能有所提高,其中记忆功能有明显改善,芪参复康胶囊改善短时记忆、瞬时记忆的疗效优于氟西汀。OBJECTIVE, To explore the change of memory function and evenrrelated potentials （ERPs） before and after treatment in firsrepisode depressions patients given with Qishen Fukang capsules （QSFK）. METHODS 70 depressed patients with first-episode were enrolled as research group and randomly divided into QSFK treated group （Chinese medicines group, CMG, 35 cases） and fluoxetine treated group （Western medicines group, WMG, 35 cases）. The research groups were assessed with 24-item Hamilton Depression Scale （HAMD） and measured with Wechsler memory scale （WMS） and evoked event-related potential P300 change before and after 12 weeks treatment. Another 34 healthy subjects were involved as controls and they were given simultaneously the same tests. And compared the effects of QSFK and fluoxetine on memory function in first-epi sode depressions before and after treatment. RESULTS （1） Compared with prior-treatment, the HAMD scores of patients ECMG（11.1 ± 3.2）score vs （31）. 1 ± 6. 2）score; WMG（13. 3 ± 3.4）score vs （29.4 ± 5.4）score] were decreased significantly （P〈0. 05） post-treatment. The HAMD reductive rate in CMG was significantly higher than the WMG ±（63.1 ± 4. 6） % vs （55.1 ± 4. 1） ±/00, P〈±0. 05]. （2）Compared with prio-treatment, the long; term memory, short term memory, immediate memory in creased significantly and MQ increased significantly after 12 weeks treatment in first-episode depressions given QSFK and fluoxetine （P〈0. 05）. Compared with the control group, no difference was found on the short term memory and immediate mere ory in CMG （P〉0. 05）, but these were decreased significantly in WMS （P（0. 05）. （3）Compared with prior-treatment, the latency of P3 was shorter ECMG.. （322. 2 ± 20. 6）ms vs （378. 4 ± 35.8）ms; WMG： （316. 8 ± 41.3）ms vs （376. 8 ± 38. 1）ms, P 〈0. 01] and the amplitude of P3 was higher [CMG： （9. 0 ± 2.2）μV vs （3. 3 ± 1.4）btV; WMG： （8.4 ± 1.6）μV vs （3.4 ± 1.2

关 键 词：芪参复康胶囊 首发 抑郁症 记忆功能 事件相关电位(ERPs) 

分 类 号：R969.4[医药卫生—药理学]