特发性室性早搏不同负荷与心脏结构和心功能关系的临床研究  

The relationship between PVC burden and cardiac structure,as well as cardiac function

作　　者：彭珍云[1] 向力群[2] 曾向辉[1] 刘振芳[1] 张翼[1] 

机构地区：[1]湖南师范大学第一附属医院心内科,长沙市410005 [2]湖南师范大学第一附属医院超声科,长沙市410005

出　　处：《实用医学杂志》2013年第2期222-224,共3页The Journal of Practical Medicine

摘　　要：目的:探讨特发性室早不同负荷与心脏结构和心功能的关系。方法:经剔除后入选152例特发性室早患者,根据动态心电图结果分为高负荷组(>20%,n=65),中负荷组(10%～20%,n=58),低负荷组(<10%,n=29)。采用二维心脏超声分别测绘观察对象左室射血分数(LVEF)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)及血清N-末端脑钠肽(NT-proBNP)水平。结果:室早负荷与LVEF呈直线负相关(r=-0.61,P<0.01);与LVESD(r=0.48,P<0.01)、LVEDD(r=0.67,P<0.01)、NT-proBNP(r=0.41,P<0.05)呈正相关。结论:随着室早负荷增大,左室呈现扩大趋势,心功能呈下降趋势。Objective The purpose of this study was to vestigate the relationship between PVC burden and cardiac structure, as well as cardiac function. Methods 152 cases of patients with premature ventricular contractions were divided into high-load group （〉 20%, n = 65）, medium load group （10% - 20%, n = 58）, low-load group （〈 10%, n = 29） according to the 24-hour ambulatory ECG results. Followed-up for 4 years, All patients underwent two-dimensional echocardiography to assess left ventricular ejection fraction （LVEF）, end systolic diameter （LVESD）, end-diastolic diameter （LVEDD）. Measure the serum N-terminal brain natriuretic peptide （NT-proBNP） level of the patients with Idiopathic premature ventricular contractions. Results The PVC burden were negatively correlated with LVEF（r = -0.61 ,P 〈 0.01 ）, and positivly correlated with LVESD（r = 0.48 ,P 〈 0.01 ）,LVEDD （r = 0.67,P 〈 0.01）,NT-proBNP （r = 0.41,P 〈 0.05）. Conclusion With PVC burden increasing, the left ventricle shows a tendency to expand and cardiac function shows a downward trend.

关 键 词：特发性室性早搏 室早负荷 心脏结构 心功能 

分 类 号：R541.7[医药卫生—心血管疾病]