肾移植术后蛋白尿病因及转归的临床研究  

Clinical research on the cause and turnover of proteinuria after renal transplantation

作　　者：赵国志[1] 刘阳[1] 赖永通[1] 陈志勇[1] 郭雪坤[1] 黄先恩[1] 林民专[1] 

机构地区：[1]广州医学院第三附属医院器官移植科,510150

出　　处：《实用医学杂志》2013年第2期233-235,共3页The Journal of Practical Medicine

基　　金：广东省自然科学基金资助(编号:10451015001004853)

摘　　要：目的:研究肾移植术后蛋白尿形成的主要原因及转归。方法:对105例肾移植术后蛋白尿患者进行回顾分析,研究其形成病因及其与转归的关系。结果:在105例肾移植尿蛋白患者中,由于排斥反应引起的占55.2%,由新发或复发性肾病引起的占34.3%,其余高血压、CNI肾毒性等原因的占10.5%。术后排斥反应和新发或复发性肾病导致肾移植术后蛋白尿总治愈率分别为93.10%和91.67%,两组比较差异无统计学意义(P>0.05)。与由高血压等其他原因所致蛋白尿患者比较,差异均有统计学意义(P<0.05)。结论:导致肾移植术后蛋白尿的主要原因是排斥反应和新发或复发性肾病,应根据移植肾穿刺后病理学诊断,及早进行相应临床治疗,以免造成不可逆性移植肾损伤。Objective To study the cause and turnover of proteinuria after renal transplantation. Methods One hundred and five patients with proteinuria after renal transplantation were retrospectively analyzed to study the cause and turnover. Results Within the 105 cases, the percent of proteinuria caused by rejection and nephrosis were 55.2% and 34.3% respectively, while caused by the other reasons such as hypertension and renal toxicity resulted in CNI was 10.5%. The total cure rates of patients with proteinuria caused by rejection and nephrosis were no significant difference （P 〉 0.05）, which were 93.10% and 91.67% respectively. But when compared to patients with proteinuria caused by other reasons, there was significant difference between them （P 〈 0.05）. Conclusions The main causes of proteinuria after renal transplantation are rejection and nephrosis. In order to avoid irreversible renal allograft damage, proper clinical measurements based on biopsy results of proteinuria should be carried out as soon as possible.

关 键 词：肾移植 蛋白尿 病因 转归 

分 类 号：R699[医药卫生—泌尿科学]