脉冲宽度对除颤效果的影响  

The effects of pulse duration on efficacy of ventricular defibrillation

作　　者：谷云飞[1] 金军[1] 薛书峰[1] 陈剑锋[1] 贺慧娟[1] 段卡丹[1] 张守彦[1] 

机构地区：[1]郑州大学附属洛阳中心医院心内科,河南省洛阳市471000

出　　处：《实用医学杂志》2013年第2期258-260,共3页The Journal of Practical Medicine

摘　　要：目的:通过动物实验,探讨不同脉冲宽度对室颤(VF)除颤效果的影响。方法:交流电刺激诱发猪VF,随机采用4ms+1ms+4ms和5ms+1ms+5ms两组不同脉冲宽度的双相波除颤,记录除颤成功次数,评价除颤阈值,统计比较两组除颤效果。结果:诱发VF80次,除颤成功25次。两组总的放电电压、能量、电量及除颤成功率无统计学差异;除颤阈值4ms+1ms+4ms组低于5ms+1ms+5ms组。结论:脉冲宽度对除颤效果有影响,适当缩短脉冲宽度,可以减小除颤阈值并有提高除颤成功率的趋势。Objective The aim of this study was to evaluate the effect of pulse duration on efficacy of ventricular defibrillation using automated external defibrillator （AED）. Methods The pig＇s ventrieular fibrillation （VF） was induced through alternating current （AC）,then the pigs randomly received defibrillation with biphasic waveforms which pulse duration was 4 ms ＋ 1 ms ＋ 4 ms or 5 ms ＋ 1 ms ＋ 5 ins.Defibrillation thresholds （DFTs） and success rates were determined and analyzed by statistics. Results There are induced VF 80 episode and 25 achieve success.The two groups have no significant difference on total shock voltage , energy and electric quantity. But the defibrillation threshold of voltage , energy and electric quantity of 4 ms ＋ 1 ms ＋ 4 ms group were lower compare with 5 ms ＋ 1 ms ＋ 5 ms group（254.337 ＋ 93.191V Vs 310.818 ± 86.534V, P= 0.023; 9.811 ＋ 5.167J Vs 11.340 ± 8.086 J, P=0.047; 0.031 ± 0.011C Vs 0.037 ＋ 0.010C, P= 0.022）. Conclusion The pulse duration is an important influence factor for defibrillation efficacy and we may decrease DFTs by shorten the pulse duration.

关 键 词：体外自动除颤器 脉冲宽度 电击除颤 

分 类 号：R541.7[医药卫生—心血管疾病]