抗氧化剂左卡尼汀在IVF中的应用  

Application of the antioxidant of L-carnitine in IVF cycles

作　　者：黄映琴[1] 覃爱平[1] 孙惟佳[1] 靳玉甫[1] 李柳铭 欧奇志[1] 

机构地区：[1]广西医科大学第一附属医院生殖医学研究中心,530000

出　　处：《实用医学杂志》2013年第2期299-301,共3页The Journal of Practical Medicine

基　　金：广西医疗卫生重点科研课题(编号:200836)

摘　　要：目的:探讨抗氧化剂左卡尼汀在IVF-ET治疗中的临床疗效。方法:选择2011年5月至2011年9月在我院生殖中心初次行IVF治疗者130例,随机分为两组。左卡尼汀(L-carnitine)用药组为研究组(57例),非用药组为对照组(73例)。比较两组的临床结局情况。结果:研究组在HCG日的E2水平、受精数、卵裂数、优质胚胎数、可移植胚胎数均高于对照组,差异有统计学意义(P<0.05),而获卵数、生化妊娠率、胚胎种植率、临床妊娠率、流产率无显著区别(P>0.05)。研究组中年龄<35岁者与对照组年龄相匹配者相比,HCG日的E2水平、受精数、卵裂数、优质胚胎数、可移植胚胎数差异均有统计学意义(P<0.05),年龄≥35岁者无差异(P>0.05)。结论:左卡尼汀在IVF治疗中能提高部分患者卵子质量,促进卵子成熟,有利于早期胚胎的形成及发育。年龄<35岁者明显。Objective To invetigate the efficacy of a treatment with antioxidant of L-camitine in women undergoing in vitro fertilization （IVF） cycles. Methods One hundred and thirty women undergoing first IVF cycles ingrour center were analyzed from May to September 2011. All women were randomized into the control group and the study group. Women in the study group （n = 57） received L-carnitine, but women in the control group （n = 73） didn＇t received L-carnitine. Clinical effects of women in these two groups were compared. Results The level of estradiol （E2） on the day of hCG injection, number of fertilization, number of embryo cleavage , number of perfect embryos and total number of embryos available in the study group were higher than those in the control group （P 〈 0.05）, but no significant difference in total number of oocytes retrieved, biochemical pregnancy rate, implantation rate, pregnant rate and abortion rate was found between these two groups. Significant increases in the level of estradiol （E2） on the day of hCG injection, number of fertilization, number of embryo cleavage , number of perfect embryos and total number of embryos available were shown in the women younger than 35 years old, not in those older than 35 years old, in the study group compared to those in the control group （P 〈 0.05, respectively）. Conclusions L-carnitine could improve oocyte quality, enhance the number of mature oocytes, and increase the number of early embryonic formation and blastocyst development in some women, especially for the women younger than 35 years old.

关 键 词：左卡尼汀 体外受精-胚胎移植(IVF—ET) 受精数 优质胚胎数 临床妊娠率 

分 类 号：R714.8[医药卫生—妇产科学]