香青兰总黄酮对支气管哮喘大鼠Th1/Th2免疫失衡的调节作用  

Effects of Moldavica Total Flavone on Regulation of Th1/Th2 Imbalance in Ovalbumin-induced Asthmatic Rats

作　　者：闫丽丽[1] 康小龙[2] 何承辉 邢建国 

机构地区：[1]石河子大学药学院药理系,新疆石河子832000 [2]新疆医科大学附属中医医院药理研究室,乌鲁木齐830000 [3]新疆维吾尔自治区药物研究所药剂室,乌鲁木齐830004

出　　处：《中国医科大学学报》2013年第1期8-9,13,共3页Journal of China Medical University

基　　金：国家自然科学基金资助项目(81060358)

摘　　要：目的观察香青兰总黄酮对支气管哮喘大鼠辅助T淋巴细胞1(Th1)/辅助T淋巴细胞2(Th2)细胞因子失衡的调节作用。方法采用卵白蛋白致敏和激发建立大鼠哮喘模型,给予香青兰总黄酮进行干预后,ELISA法检测大鼠支气管肺泡灌流液中白介素4(IL-4)、干扰素γ(IFN-γ)及嗜酸粒细胞趋化蛋白1(Eotaxin-1)的水平。结果香青兰总黄酮可剂量依赖性的降低哮喘大鼠支气管肺泡灌流液中IL-4和Eotaxin-1含量,升高IFN-γ含量,减小IL-4/IFN-γ比值(P<0.05或0.01)。结论香青兰总黄酮对支气管哮喘Th1/Th2免疫失衡有一定调节作用。Objeelive To investigate the effects of moldavica total flavone on immunologic balance of helper T lymphocyte 1 （Thl）/helper T lymphocyte 2 （Th2） in ovalbumin-induced asthmatic rats. Methods Rats asthma model was established by ovalbumin challenge meth- ods. After moldaviea total flavones treatment,interleukin-4 （IL-4）,interferon-γ （IFN-γ） and Eotaxin-1 in bronehoalveolar lavage fuid （BALF） were respectively detected by ELISA. Resdts The levels of IL-4,Eotaxin-1 and ratio of IL-4/IFN-γ in ovalbumin-indueod asth- matic rats were markedly decreased and the level of IFN-γ dramatically increased （P 〈 0.05 or P 〈 0.01 ） after administration of moldaviea total flavone. Conclusion Moldaviea total flavone is effective in treating asthma by adjusting immunologic imbalance of Th1/Th2.

关 键 词：香青兰总黄酮 支气管哮喘 辅助T淋巴细胞 免疫失衡 

分 类 号：R965.1[医药卫生—药理学]