系统性红斑狼疮患者尿N-乙酰-β-氨基葡萄糖苷酶水平及其临床意义的研究  

The Level of Urinary N-acetyl-β-D-glucosaminidase in Systemic Lupus Erythematosus Patients

作　　者：赵珊[1] 孙婷婷[1] 李羽佳[1] 吴可非[1] 田百玲[1] 刘旭东[1] 赵萌萌[1] 杨娉婷[1] 肖卫国[1] 

机构地区：[1]中国医科大学附属第一医院风湿免疫科,沈阳110001

出　　处：《中国医科大学学报》2013年第1期35-37,共3页Journal of China Medical University

基　　金：国家自然科学基金资助项目(81271324);辽宁省自然科学基金资助项目(201202250);辽宁省医学高峰建设工程重点科研项目(200932;2010006)

摘　　要：目的探讨系统性红斑狼疮(SLE)患者尿中N-乙酰-β-氨基葡萄糖苷酶(NAG)水平及其临床意义。方法根据尿微量蛋白结果将65例SLE患者分为单纯肾小管受累组(n=30)和肾小管与肾小球均受累组(n=35)。21例健康体检者作为对照组。散射比浊法和比色法检测尿中NAG水平。结果组间比较显示:单纯肾小管受累组和肾小管与肾小球均受累组的尿NAG水平均显著高于对照组(P<0.05),而单纯肾小管受累组和肾小管与肾小球均受累组的尿NAG水平无明显差异(P>0.05)。65例SLE患者尿NAG与尿β2-微球蛋白呈显著的正相关性(r=0.96,P<0.05)。结论 SLE患者的尿检结果提示肾小管的病变可单独存在,而肾小球病变与肾小管病变同时存在。狼疮肾炎患者尿NAG水平显著增高,且与肾小管病变密切相关。Objective To explore the level of N-acetyl-β-glucosaminidase （NAG） and its clinical significance in patients with systemic lu- pus erythemalosus （SLE）. Methods According to the results of urine micro-protein, sixty-five patients with SLE were reeruited and divided into simple tubular involvement group （n =30） and renal tubular as well as glomerular involvement group （n =35 ）. There was no patient with simple glomerular involvement. Twenty-one age- and sex-matehed healthy individuals were enrolled as eontvol. NAG was deteeted by seattering turbidimetry and colorimetry. Results The levels of urinary NAG were significantly higher in the simple tubular involvement group and renal tubular as well as glomerular involvement group compared with the control group （ P 〈 0.05 ）. There was no significant dif- ference between the simple tubular involvement group and renal tubular as well as glomerular involvement. Positive correlation was found be- tween urinary NAG and urinary β2-micro-globulin in 65 patients （r =0.96, P 〈 0.01 ）. Conclusion Renal tubular lesions can exist alone in patients with lupus nephritis. Urinary NAG is a useful marker for the detection of renal involvement in lupus nephritis.

关 键 词：系统性红斑狼疮 N-乙酰-Β-氨基葡萄糖苷酶 Β2-微球蛋白 

分 类 号：R593.24[医药卫生—内科学]