心肌细胞葡萄糖转运蛋白4的转运调控及与心肌活力关系的研究进展  

Recent advances on the regulation of glucose transporter 4 transport and its relationship with myocardial viability in cardiomyocytes

作　　者：蔡琳婷[1] 陈文新[1] 

机构地区：[1]福建医科大学省立临床医学院核医学科,福州350001

出　　处：《国际放射医学核医学杂志》2013年第1期47-51,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：福建省自然科学基金（2010J01128）

摘　　要：葡萄糖是心肌能量代谢的主要底物之一，在心肌缺血时是心肌的主要能量来源。葡萄糖通过细胞膜进入细胞内是心肌细胞葡萄糖代谢的第一步，也是心肌细胞利用葡萄糖的主要限速步骤。葡萄糖是依靠细胞膜上的葡萄糖转运蛋白（GLUTs）而进入细胞内的，GLUT4是心肌细胞主要的葡萄糖转运载体。GLUT4的质和量对心肌葡萄糖的跨膜转运起着决定性作用。因此，明确心肌葡萄糖转运及心肌细胞GLUT4的基因表达调控机制、转位调控机制、内在活性调控机制，对临床诊断心肌能量代谢性疾病具有重要意义。该文对近年来有关心肌葡萄糖转运及GLUT4调控方面的研究进行综述。Glucose plays an important role in cardiac metabolism. It is the major energy source during myocardial ischemia. Trans-membrane glucose transport is the first rate-limited step for myocardial glu- cose metabolism, which is facilitated by glucose transports （GLUTs） and GLUT4 represents an important mechanism that governs the entry of glucose into the heart. The quality and quantity of GLUT4 play a decisive role in transmembrane glucose transport. To better retrieve myocardial metabolism and improve myocardial function under myocardial isehemia conditions, it is urgent to elucidate the regulatory mechanism of GLUT4 expression, the regulatory mechanism of GLUT4 translocation, the regulatory mechanism of GLUT4 intrinsic activity and glucose transport in cardiomyocytes. This review summarized the current state of knowledge regarding the regulation of GLUT4 functioning and glucose transport in cardiomyocytes.

关 键 词：葡萄糖转运蛋白质类 易化性 葡萄糖转运体4型 肌细胞 心脏 心肌缺血 

分 类 号：R54[医药卫生—心血管疾病]