冠心病患者中代谢综合征组分数目与冠状动脉病变严重程度的相关性研究  

Relationship between the number of metabolic syndrome components and severity of coronary artery lesions in patients with coronary heart disease

作　　者：倪亚芳[1] 冯波[1] 王华[1] 胡铂[1] 陆玮新[1] 刘风静[1] 

机构地区：[1]上海同济大学附属上海东方医院内分泌科,200120

出　　处：《中国糖尿病杂志》2013年第1期39-41,共3页Chinese Journal of Diabetes

基　　金：国家973计划(2006CB503900)

摘　　要：目的了解冠心病患者MS各组分与冠状动脉病变严重程度的关系。方法将本院行冠状动脉造影的274例冠心病患者分为MS组和非MS(NMS)组,进行统计学分析。结果 MS组多支病变率(≥2支)、Gensini积分高于NMS组。随着代谢异常组分个数的增加,多支病变率、Gensini积分也随之增加。同时,按照冠状动脉病变支数、Gensini积分四分位分组,随着病变严重程度的增高,MS患病率也增加。Logsitic回归分析提示餐后血糖、BMI是冠状动脉病变严重程度的独立危险因素。结论MS与冠脉病变严重程度关系密切。随着代谢异常组分个数的累积,冠脉病变严重程度增加。餐后血糖及体重对冠状动脉病变的影响尤为重要,应引起重视。Objective To screen metabolic syndrome in patients with coronary heart disease （CHD） in order to find out high-risk people of cardiovascular disease and study the relationship between metabolic syndrome components and severity of coronary artery lesions. Methods Angiographies of coronary arteries were performed in 274 CHD cases. They were divided into MS group and non-metabolic syndrome （NMS） group according to CDS standard. Regults The incidence of multi-branch （~2） lesion was higher in the MS group. Gensini scores increased in the MS group compared with that in the NMS group. The incidence of multi-branch lesion and the Gensini score increased with the increase in number of metabolic syndrome components. MS prevalence was increased with the increase in both branch number and quartile of Gensini score. Logistic regression analysis revealed that the postprandial blood glucose and BMI were independent risk factors for CHD. Conclusion There is close relationship between metabolic syndrome and the severity of coronary heart disease. The severity of coronary artery lesions increase with the increase in metabolic syndrome components. More attention should be paid to the postprandial blood glucose and BMI because they play a more important role in severity of coronary artery lesion.

关 键 词：代谢综合征 冠脉病变 冠脉造影 

分 类 号：R541.4[医药卫生—心血管疾病]