syndecan-1在2型糖尿病患者白细胞表面表达的研究  

Expression of syndecan-1 on leukocytes in patients with type 2 diabetes mellitus

作　　者：王静波[1] 关娟[1] 张妍[2] 周历[1] 盛豫[1] 司艳芳[1] 

机构地区：[1]解放军第309医院眼科,北京100091 [2]解放军第309医院内分泌科,北京100091

出　　处：《中国糖尿病杂志》2013年第1期57-59,共3页Chinese Journal of Diabetes

基　　金：首都卫生发展科研专项(首发2011-5007-02)

摘　　要：目的检测T2DM患者外周血白细胞表面syndecan-1的表达。方法通过流式细胞仪检测外周血白细胞亚群(中性粒细胞、单核细胞、淋巴细胞)上syndecan-1的表达,并分析syndecan-1的表达与多项临床参数的相关性。结果将29例无并发症的T2DM患者(T2DM组)和24名年龄匹配的健康对照(NC组)者纳入研究。在中性粒细胞,T2DM组syndecan-1阳性细胞率(10.372±1.767)%较NC组(3.988±0.673)%升高(P=0.002)。单核细胞T2DM组syndecan-1阳性细胞率(2.221±0.310)%与NC组(2.975±0.553)%比较差异无统计学意义(P=0.241)。淋巴细胞T2DM组syndecan-1阳性细胞率(25.093±3.865)%与NC组(19.520±3.283)%比较差异无统计学意义(P=0.288)。T2DM组中,中性粒细胞syn-decan-1阳性细胞率与BMI呈正相关(r=0.572,P=0.004)。结论 T2DM患者外周血中性粒细胞表面syndecan-1的表达增强,其阳性表达率与BMI呈正相关。Objective To detect the expression of syndecan-1 on leukocytes in patients with type 2 diabetes mellitus. Methods Expression of syndecan-1 on subsets of leukocytes （neutrophil, monocyte and lymphocyte） was determined by flow eytometry, and potential correlations between syndeean-1 and clinical characteristics were analyzed. Results Twenty-nine patients with type 2 diabetes mellitus （without any diabetic complications, T2DM group） and 24 age-matched healthy subjects （NC group） were enrolled. On neutrophils, the percentage of syndeean-l-positive cells was prominently higher in T2DM group than in NC group [（10. 372=kl. 767）% vs （3. 988±0. 673）M] （P=0. 002）. On monocytes, the difference in syndeean-l-positive ceils between NC group and T2DM group was not significant （2. 221± 0. 310）0{ vs （2. 975±0. 553）%] （P=0. 241）. On lymphocytes, the difference in syndecan-l-positive cells between NC group and T2DM group was also insignificant [（19. 520±3. 283） vs （25. 093±3. 865）%] （P = 0. 288）. In the T2DM group, the correlation between the percentage of syndecan-l-positive neutrophils and BMI was possitive （r=0. 572,P=0. 004）. Conclusion Compared with normal controls, the expression of syndecan-1 on peripheral neutrophils may increase in subjects with type 2 diabetes, and it is associated positively with BMI.

关 键 词：SYNDECAN-1 糖尿病 2型 白细胞 中性粒细胞 

分 类 号：R587.1[医药卫生—内分泌]