miRNA与胰岛素抵抗  

miRNAs and insulin resistance

作　　者：李兴[1] 凌宏艳[2] 胡弼[2] 

机构地区：[1]南华大学药物药理研究所,衡阳421001 [2]南华大学医学院生理学教研室

出　　处：《中国糖尿病杂志》2013年第1期88-90,共3页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81000328)

摘　　要：IR是T2DM的主要病因之一,但其发病机制至今仍未完全阐明。尽管胰岛素信号传递缺陷被认为在IR发生过程中扮演了重要的角色,但新近研究发现,miRNAs与IR密切相关。因此,对IR相关miRNAs的研究将为进一步阐明IR发病机制提供新的思路,为早期预防和治疗IR提供新的靶点。IR is one of the main etiologies of T2DM. However, the major mechanisms underlying the pathogenesis of IR remain obscured. Although a defect in insulin signaling transduetion is considered to play an important role in the development of IR, the recent researches showed that miRNA is closely associated with IR. Therefore, studies on the IR related miRNAs will provide new ideas to further clarify the pathogenesis of IR and provide new targets for its early prevention and treatment.

关 键 词：MIRNAS 胰岛素抵抗 发病机制 T2DM 发生过程 信号传递 早期预防 IR 

分 类 号：R587.1[医药卫生—内分泌]