4-羟基-3-(2-亚氨基乙基)-2H-苯并吡喃-2-酮类化合物的超声辐射合成  

Synthesis of 4-Hydroxy-3-(2-imino ethyl)-2H-chromen-2-one Derivatives under Ultrasound Irradiation

作　　者：王慧彦[1,2] 周丹丹[1] 陈秭君 

机构地区：[1]淮海工学院化学工程学院,连云港222005 [2]江苏省有机合成重点实验室苏州大学材料与化学化工学部,苏州215123

出　　处：《应用化学》2013年第2期153-158,共6页Chinese Journal of Applied Chemistry

基　　金：淮海工学院大学生创新实验项目;江苏省普通高校研究生科研创新计划资助项目(CXZZ11_0090)

摘　　要：以乙醇为溶剂,4-羟基-3-乙酰基香豆素和胺为原料,对甲苯磺酸为催化剂,在超声波作用下合成一系列4-羟基-3-(2-亚氨基乙基)-2H-苯并吡喃-2-酮类化合物,产率62%～94%。对产物进行了IR、1H NMR及HRMS表征,对化合物3c进行了X射线衍射分析。该方法具有反应产率高、时间短、反应条件温和及操作简单等优点。A series of 4-hydroxy-3-（2-imino ethyl）-2H-chromen-2-ones was first synthesized by the reaction of 4-hydroxy-3-acetyl coumarin and amines in alcohol with 4-methylbenzenesulfonic acid as catalyst under ultrasonic irradiation. The yields were in the range of 62% - 94%. The structures of the products were confirmed by IR, I H NMR and HRMS. The structure of compound 3c was determined by X-ray single-crystal diffractions. The advantages of this method are high yield, shorter reaction time, mild condition and simple work-up procedures.

关 键 词：SCHIFF碱 羟基乙酰基香豆素 超声辐射 合成 

分 类 号：O626[理学—有机化学]