NQO1基因C609T、C465T多态性与子宫内膜癌易感性的关系  

Correlation between NQO1 gene C609T,C465T polymorphisms and the risk of endometrial cancer

作　　者：李利[1] 高会影[1] 杨威威[1] 李方[1] 程建新[1] 

机构地区：[1]河北医科大学第四医院,石家庄050011

出　　处：《山东医药》2013年第3期15-18,共4页Shandong Medical Journal

基　　金：河北省自然科学基金资助项目(C2006000857);河北省高校强势特色学科资助项目(冀教高[2005]52号)

摘　　要：目的探讨醌氧化还原酶1(NQO1)基因第六位外显子(C609T)、第四位外显子(C465T)单核苷酸多态性与子宫内膜癌易感性的关系。方法采用PCR-RFLP法检测209例子宫内膜癌患者(观察组)和209例健康体检女性(对照组)NQO1 C609T、NQO1 C465T的基因型,并统计等位基因,分析其与子宫内膜癌易感性的关系。结果观察组NQO1 C609T基因型C/C分布低于对照组,基因型T/T、C/T及等位基因T分布高于对照组(P均<0.05);两组NQO1 C465T基因型及等位基因分布比较,P均>0.05。观察组初潮年龄<15岁者NQO1 C609T基因型C/C分布低于对照组,T/T、C/T分布高于对照组(P均<0.01);观察组未绝经者NQO1 C609T基因型C/C分布低于对照组,T/T、C/T分布高于对照组(P均<0.01)。结论 NQO1 C609T多态性与子宫内膜癌的发病有关,携带T等位基因可能增加子宫内膜癌的发病风险。Abstract： Objective To investigate the association of quinine oxidoreductasel （ NQO1 ） C609T and CA65T gene pol- ymorphisms with the risk of endometrial cancer. Methods NQO1 C609T和NQO1 C465T genotypes were analyzed by pol- ymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method in 209 endometrial cancer patients （observed group） and 209 frequency-matched control women（ control group）, allelic genes were counted and its correlation with the risk of endometrial cancer was analyzed. Results Compared with the control group, the frequency of NQO1 C609T C/C in observed group decreased significantly, the frequencies of C/T, T/T genotypes and T allele increased signif- icantly （all P 〈0.05 ）. No significant difference was found in allele frequencies and genotype distributions of NQOI C465T polymorphism between both groups （all P 〉 0.05 ）. While menarch age 〈 15, the frequency of NQO1 C609T C/C in ob- served group was higher, the frequencies of C/T, T/T genotype were lower than the control group （ all P 〈 0.05 ） ; while premenopause, the frequency of NQO1 C609T C/C in observed group was higher, the frequencies of C/T, T/T genotype were lower than the control group （ all P 〈 0.05 ）. Conclusion The NQO1 C609T gene polymoephism might be associated with endometrial cancer, and the T allele may increase the risk of endometrial cancer development.

关 键 词：子宫内膜癌 NQO1基因 单核苷酸多态性 遗传易感性 

分 类 号：R766[医药卫生—耳鼻咽喉科]