戒烟干预对不同性别吸烟慢性阻塞性肺疾病患者临床症状及肺通气功能的影响研究  

Effects of Smoking Cessation on Clincal Symptoms and Respiratory Function in Patients of Different Gender with Chronic Obstructive Pulmonary Disease

作　　者：王少飞[1] 张庆[1] 张勃[1] 宋欢欢[1] 何权瀛[2] 

机构地区：[1]承德医学院附属医院呼吸科,河北省承德市067000 [2]北京大学人民医院呼吸科

出　　处：《中国全科医学》2013年第2期136-139,共4页Chinese General Practice

基　　金：中华医学会临床医学慢性呼吸道疾病科研专项资金资助项目(07010260034)

摘　　要：目的探讨戒烟干预对不同性别吸烟慢性阻塞性肺疾病(COPD)患者临床症状和肺通气功能影响,为临床制定戒烟策略提供参考。方法选择2008年12月—2010年12月我院呼吸科接诊的男性吸烟COPD患者87例为男性组,女性吸烟COPD患者60例为女性组。对两组患者实施为期1年的戒烟干预,记录患者戒烟情况并进行亚组分析,记录患者入组时、戒烟干预1年时临床症状评分和肺通气功能,肺通气功能以1秒用力呼气容积占预计值的百分比(FEV1%Pred)表示。结果男性组成功戒烟率为40%(35/87),女性组为22%(13/60),差异有统计学意义(χ2=5.56,P=0.018)。入组时,男性成功戒烟患者临床症状评分、FEV1%Pred与女性成功戒烟患者比较,差异均无统计学意义(P>0.05);1年时比较,差异均有统计学意义(P<0.05)。男性成功戒烟患者临床症状评分平均变化量为(2.4±2.5)分,FEV1%Pred平均变化量为(3.1±2.2)%,自身前后比较,差异均有统计学意义(t值分别为6.42和8.51,P<0.05);女性成功戒烟患者临床症状评分平均变化量为(1.0±1.3)分,FEV1%Pred平均变化量为(8.4±1.7)%,自身前后比较,差异亦均有统计学意义(t值分别为2.54和17.6,P<0.05)。入组时,男性未成功戒烟患者临床症状评分、FEV1%Pred与女性未成功戒烟患者比较,差异均无统计学意义(P>0.05);1年时比较,差异均有统计学意义(P<0.05)。男性未成功戒烟患者临床症状评分平均变化量为(1.1±1.0)分,FEV1%Pred平均变化量为(4.2±3.6)%,自身前后比较,差异均有统计学意义(t值分别为5.51和8.40,P<0.05);女性未成功戒烟者临床症状评分平均变化量为(2.0±1.4)分,FEV1%Pred平均变化量为(6.8±3.5)%,自身前后比较,差异亦均有统计学意义(t值分别为5.83和13.25,P<0.05)。结论成功戒烟可改善吸烟COPD患者临床症状和肺通气功能,但女性吸烟COPD患者戒烟相对困难。吸烟COPD患者的戒烟干预效果存在性别差异,应采取有针对性的戒烟策�Objective To investigate the effects of smoking cessation on clinical symptoms and respiratory function of patients of different gender with chronic obstructive pulmonary disease （COPD）. Methods A total of 87 male COPD smokers （male group） and 60 female COPD smokers （female group） who were treated in our pulmonary clinic from December 2008 to November 2010 were enrolled in this study. Both groups were given smoking cessation interventions for one year. The clinical symptoms and respiratory function at presentation and one year later were recorded. The lung function was assessed using FEV1% Pred. Results The success rate of smoking cessation was 40% （35/87） in the male group and 22% （13/60） in the female group （χ2 = 5.56, P = 0. 018）. The clinical symptom scores and respiratory function between patients who had successfully quit smoking in both groups showed no significant difference at the enrollment （P 〉 0. 05）. One year after intervetnion, the differ- ences became statistically significant （P 〈 0. 05）. In male quitters, the average pulmonary symptom score （2. 4 ± 2. 5 ） and respiratory function （3.1 ± 2. 2） % were significantly improved when compared with the baseline （ t = 6. 42, 8.51, P 〈 0.05 ）. In female quitters, the average change of pulmonary symptoms and respiratory function were （ 1.0 ± 1.3） and （8.4 ± 1.7） %,which were also significantly improved compared with the baseline （t =2. 54, 17.6, P 〈0. 05）. At the enrollment, the clinical symptom score and respiratory function were not significantly different between male and female groups （ P 〉 0.05 ） ; One year later, however, there was a significant difference between them （P 〈0.05）. In male smokers, the average change of pulmonary symptom score and respiratory function were （ 1.1 ± 1.0） and （4. 2 ± 3.6） %, respectively, which were also significantly improved when compared with the baseline （t = 5.51, 8.40, P 〈 0.05）. In female smokers, the average change of p

关 键 词：肺疾病 慢性阻塞性 性别分布 戒烟 呼吸功能试验 

分 类 号：R563.8[医药卫生—呼吸系统] R163.1[医药卫生—内科学]