急性ST段抬高型心肌梗死患者心型脂肪酸结合蛋白水平与GRACE危险评分的相关性研究  

Relationship between Heart-type Fatty Acid-binding Protein and GRACE Risk Score in Patients with Acute ST-elevation Myocardial Infarction

作　　者：魏庆民[1] 周彬[1] 王晓纲[1] 樊延明[1] 王爱平[1] 刘翠华[1] 

机构地区：[1]河北省邢台市人民医院心脏内科,054031

出　　处：《中国全科医学》2013年第2期144-146,共3页Chinese General Practice

基　　金：河北省科技支撑计划项目(11276103D-79)

摘　　要：目的探讨急性ST段抬高型心肌梗死(STEMI)患者血浆心型脂肪酸结合蛋白(H-FABP)的峰值水平与全球急性冠状动脉事件注册(GRACE)风险评分的相关性。方法选择2010年4月—2011年12月我科收治的发病2 h内的STEMI患者60例,于患者发病后2、4、6、8、10、12 h采血,检测H-FABP水平,找出其峰值。记录患者的基线资料,计算GRACE风险评分,对GRACE评分和H-FABP的峰值水平进行Pearson直线相关分析。结果H-FABP的达峰时间为4～8 h,平均峰值为(59.4±23.1)μg/L;STEMI患者H-FABP峰值水平与GRACE危险评分呈正相关(r=0.701,P<0.05)。结论 STEMI的H-FABP峰值水平与GRACE评分相关,检测H-FABP峰值水平可以为STEMI患者的危险分层提供参考。Objective To study the relationship between heart -type fatty acid -binding protein （H -FABP） level and Global Registry of Acute Coronary Events （GRACE） risk score in patients with acute ST - elevation myocardial infarction （STEMI）. Methods From April 2010 to December 2011, 60 STEMI patients admitted to our hospital within 2 hours of symptom onset were enrolled in this study, Twelve hours after admission, blood samples were obtained for H - FABP measurement every two hours. Then, H - FABP peak values were found. The baseline data were recorded and the GRACE risk score were cal- culated. The Pearson＇s correlation analysis were used to analyze the relationship between the H - FABP peak value and GRACE risk score. Results The peak value of H - FABP was （59.4 ＋ 23.1 ） μg/L, which occured 4 - 8 hours after admission. It was positively correlated with GRACE risk score in these patients （ r = 0. 701, P 〈 0. 05）. Conclusion H - FABP peak value is directly relevant with GRACE risk score in STEMI patients. Measurement of H - FABP level can provide additional risk stratifi- cation information in these patients.

关 键 词：急性ST段抬高型心肌梗死 心型脂肪酸结合蛋白 全球急性冠状动脉事件注册危险评分 

分 类 号：R541.4[医药卫生—心血管疾病]