瘦素与心血管疾病的相关性研究进展  

Research Progress in Correlation between Leptin and Cardiovascular Diseases

作　　者：覃泱[1] 徐彤彤[2] 武琦[2] 吕祥威[2] 

机构地区：[1]桂林医学院附属医院内科学教研室,广西桂林市541004 [2]桂林医学院附属医院特需病区

出　　处：《中国全科医学》2013年第2期226-228,共3页Chinese General Practice

基　　金：2011广西壮族自治区科技厅广西科学研究与技术开发计划项目课题(桂科攻1140003B-76);2010广西医疗卫生重点科研课题(重2010050);2012广西卫生厅课题(Z2012417)

摘　　要：瘦素是由肥胖基因编码的一种蛋白质产物,主要在白色脂肪组织中表达。已有研究证明其在心肌、乳腺、骨骼肌、肺组织、胃黏膜等中均有不同程度的表达,其作用途径主要是通过与受体结合产生抑制食欲、减少能量摄入、增加能量消耗等生物学效应,并参与神经内分泌疾病、炎症反应、免疫调节、呼吸疾病、肥胖症等多种疾病的发生与发展。近年来研究显示,瘦素是心血管疾病发生发展的重要因素,本文即对瘦素与心血管相关疾病的关系研究进展做一综述。Leptin is a kind of protein product produced by obese gene coding, mainly expressed in white adipose tissues. It has been proved to be expressed at varying degrees in myocardial, mammary glands, skeletal muscle, lung tissues, gastric mucosa, etc. Its effective pathway is, through its combination with receptors, producing such biological effects as suppression of appetite, reduction of energy intake, increase of energy consumption etc. and participating in the occurrence and development of neuroendocrine diseases, inflammation reaction, immune regulation, respiratory diseases, obesity and other diseases. Recent researches have shown that leptin is an important factor for the occurrence and development of cardiovascular diseases. This paper reviews the progress in research of relationship between leptin and cardiovascular diseases.

关 键 词：瘦素 心血管疾病 综述 

分 类 号：R54[医药卫生—心血管疾病]