心脉隆注射液治疗住院高龄慢性心力衰竭患者的临床疗效观察  

Clinical Effect of Xinmailong Injection in the Treatment of Chronic Heart Failure in Advanced Age Patients

作　　者：黄方[1] 张瑗[1] 方放[1] 钱晓明[1] 

机构地区：[1]中国人民解放军南京军区老年病研究中心,南京军区总医院干部病房二科,江苏省南京市210002

出　　处：《中国全科医学》2013年第3期329-331,共3页Chinese General Practice

基　　金：南京军区医学科技创新资助课题(11MA097)

摘　　要：目的探讨心脉隆注射液治疗住院高龄慢性心力衰竭(CHF)患者的疗效及安全性。方法将2008年6月—2011年6月住院的117例高龄CHF患者〔纽约心脏病协会(NYHA)心功能分级Ⅲ～Ⅳ级〕分为治疗组71例和对照组46例,两组均按照《慢性心功能衰竭诊断治疗指南》进行治疗,对照组使用利尿剂、血管紧张素转换酶抑制剂(ACEI)及酌情使用硝酸脂类、洋地黄类药物,治疗组在此基础上加用心脉隆注射液8 ml+5%葡萄糖注射液或0.9%氯化钠溶液100 ml静脉滴注,1次/d,连用14 d。比较两组治疗后的临床效果、左心室射血分数(LVEF)和N端B型脑钠肽前体(NT-proBNP)水平的变化。结果对照组显效22例、有效17例、无效7例,治疗组显效50例、有效18例、无效3例,两组治疗效果间差异有统计学意义(u=-2.6375,P=0.0084)。治疗后治疗组LVEF高于对照组,NT-proBNP水平低于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论心脉隆注射液可降低高龄CHF患者心脏负荷,抑制神经内分泌激活,改善心功能。Objective To investigate the curative effect and safety of Xinmailong injection in treating chronic heart failure（CHF） among advanced age patients. Methods 117 advanced age CHF patients with cardiac functional grading from Ⅲ to Ⅳ June 2008 to June 2011 were divided into treatment group（71 cases） and control group（46 cases）.The two groups were treated according to CHF treatment guide.The control group was given diuretic,angiotensin converting enzyme inhibitor and appropriate levels of nitric acid lipide and digitaloid drugs,while the treatment group was given additional intravenous drip of Xinmailong injection and 100 ml 5 percent glucose injection or 0.9 percent sodium chloride solution one time daily for 14 consecutive days.The changes of clinical effect,left ventricular ejection fraction（LVEF） and NT-proBNP after treatment were compared between the two groups. Results In the control group,22 cases were significantly improved,17 cases were improved and 7 cases were invalid,while in the treatment group,50 cases were significantly improved,18 cases were improved and 3 cases were invalid.The difference between the two groups was statistically significant（u=-2.6375,P=0.0084）.After treatment,the LVEF of treatment group was significantly higher than the control group,and the NT-proBNP was significantly lower than the control group（P0.05）.The adverse effect rate of the two groups showed no statistically significant difference（P0.05）. Conclusion Xinmailong injection can lower cardiac load of CHF among advanced age patients,restrain activation of neuroendocrine and improve heart function.

关 键 词：慢性心力衰竭 心脉隆注射液 老年人 80以上 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]