聚羟基丁酸羟基辛酸关节一体化组织工程支架制备条件及性能优化  

Optimization of the Preparation Conditions and Properties of a Poly(Hydroxybutyrate-co-hydroxyoctanoate) Articular Integrative Tissue-engineering Scaffold

作　　者：杜美丽[1] 张永红[2] 吕利华[1] 刘坚[1] 陈学英[3] 赵良启[1] 

机构地区：[1]山西大学化学生物学与分子工程教育部重点实验室,山西太原030006 [2]山西医科大学第二医院骨科,山西太原030001 [3]山西省医用组织库,山西太原030006

出　　处：《山西大学学报（自然科学版）》2013年第1期108-112,共5页Journal of Shanxi University(Natural Science Edition)

基　　金：国家自然科学基金(31040030)

摘　　要：根据仿生学原理,设计与制备了软骨层/过渡层/硬骨层仿生关节一体化组织工程支架,并优化了其制备条件及性能.结果显示:支架各层结构合理、连接紧密,生物相容性好,亲水率最高能达到200%以上,骨髓间充质干细胞在支架上生长良好.According to the principles of bionics, the cartilage layer/interlayer/bone layer bionic joint inte- grative tissue-engineering scaffold was designed and prepared, and its preparation conditions and properties were optimized. The results indicated that the layers of the integrative scaffold were reasonably structured, closely connected,and its hydrophilicity can reach up to 200%. The bone marrow mesenchymal stem cells grew well on the scaffold,which laid a foundation for the applications of this integrative scaffold in joint tissue engineering.

关 键 词：关节损伤修复 关节一体化组织工程支架 聚羟基丁酸羟基辛酸 脱细胞基质 骨髓间充质干细胞 

分 类 号：Q819[生物学—生物工程]