低危影响复极的药物致心律失常的危险性  

Proarrhythmic Potential of Low-risk Drugs That Affect the Ventricular Repolarization

作　　者：杨巧梅[1] 吴林[1] 

机构地区：[1]北京大学第一医院心内科,北京100034

出　　处：《心血管病学进展》2013年第1期11-15,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81170156)

摘　　要：临床药物的致心律失常作用可见于多种心脏病和非心脏病用药,不同药物间致心律失常作用发生率差异大,有些药物因为致心律失常发生率低,只有在大规模应用于临床后才发现其致心律失常危险性,极易被忽视,因此,对低危药物致心律失常作用的认识具有极大的意义。当心脏存在延迟钠电流增大时,低危药物的致心律失常作用显著增加,而延迟钠电流增大可发生在多种生理、病理和药理情况下,因此在这些患者尤应注意药物致心律失常的问题。Drugs,including both cardiac and noncardiac agents, may cause proarrhythmic activities. There is a great variability in the incidence of drug-induced cardiac arrhythmias and the mechanism responsible for the difference in the incidence of torsade de pointes remains unknown. Some drugs have a very low-risk which can be found only in large scale of clinical use and easy to be neglected. Therefore, predic- tion of the proarrhythrnie activities of low-risk drugs is critically important. Recent evidence indicates that the risk of proarrhythmia of drugs is greatly increased in heart with enhanced late sodium current which is associated with variety of physiological, pathological and pharmaco- logical conditions. The proarrhythmie activities of low-risk drugs that affect the cardiac repolarization are reviewed in this artiele.

关 键 词：药物 致心律失常作用 心室复极 心律失常 延迟钠电流 

分 类 号：R541.7[医药卫生—心血管疾病]