以T-SPOT.TB检测为依据的结核病人密接者感染状况及影响因素研究  

Use of T-SPOT.TB assay in detection of latent tuberculosis infection and analysis its risk factors among the TB contacts in Songjiang district,Shanghai

作　　者：路丽苹[1] 洪建军[1] 金晓萍[1] 沈红英[1] 

机构地区：[1]上海市松江区疾病预防控制中心,上海201620

出　　处：《现代预防医学》2013年第3期568-570,共3页Modern Preventive Medicine

摘　　要：目的了解上海市松江区肺结核病人密接者潜伏结核感染的情况及影响因素分析。方法以松江区户籍人口菌阳肺结核病人及其密接者为研究对象,调查问卷的形式收集研究对象的基本信息和结核感染相关信息,结核感染T细胞斑点试验(T-SPOT.TB)技术了解结核感染情况,单因素及多因素分析影响感染状况的因素。结果研究纳入密接者144名,平均年龄44岁,男性占42.36%,T-SPOT.TB检测阳性32人,阳性率22.22%,单因素及多因素分析显示随着年龄增加及接触时间的增加,结核潜隐感染的危险性增加。结论松江区结核病人密接者结核潜隐率为22.22%,针对结核感染危险因素采取有效干预措施具有十分重要的意义。OBJECTIVE To investigate the latent tuberculosis infection （LTBI）, and to identify the risk factors among the TB contacts in Songjiang district. METHODS Questionnaire interview was applied to investigate the socio-demographic and clinical information related to LTBI among the TB contacts. RESULTS Of 144 enrolled contacts, 42.36% were men, median age was 44 years, 32 were T-SPOT.TB positive. By univariate and multivariate analysis in the Logistic regression model, old age and long time contact significantly increased the likelihood of LTBI. CONCLUSION With the use of T-SPOT.TB and chest radio- graphs, LTBI is detected in 22.22% of TB contacts, and this study highlights the significance of intervention among old age contacts and those long time in contact with TB patients.

关 键 词：结核 感染率 T—spot TB 户籍人口 

分 类 号：R521[医药卫生—内科学]