武汉地区普通人群甲型H1N1流感病毒抗体水平分析  

Analysis for H1N1 virus antibody levels in general population in Wuhan area

作　　者：刘琳琳[1] 叶国军[1] 方斌[1] 霍细香[1] 

机构地区：[1]湖北省疾病预防控制中心病原微生物检测中心,湖北武汉430079

出　　处：《现代预防医学》2013年第3期576-577,580,共3页Modern Preventive Medicine

摘　　要：目的了解武汉地区2009年第四季度至2010年第一季度普通人群中甲型H1N1流感病毒抗体水平变化,及时掌握武汉市普通人群甲型H1N1流感病毒感染状况,为评估、研判疫情发展趋势提供信息支持。方法按照时间间隔(1个月)分次采集4个年龄组普通人群的血清共2106份,采用血凝抑制实验检测人群抗体水平。结果共调查2106人,甲流抗体总阳性率为18.14%,其中男性阳性率为17.00%,女性为19.48%。经过卡方检验,不同采集时间、不同年龄组、是否接种甲流疫苗人群间的甲流抗体阳性率差异有统计学意义(P﹤0.05)。结论武汉市2009年第四季度至2010年第一季度普通人群中甲型H1N1流感病毒抗体水平平均在18%以上,但是抗体水平仍然较低;接种甲流疫苗后人群抗体水平显著高于未接种疫苗人群,说明甲流疫苗的接种对人群具有明显的保护性意义。OBJECTIVE To estimate the infection status of H1N1 virus in general population in Wuhan and provide information to predict future epidemics, we investigated H1N1 virus antibody levels in Wuhan during the 4th quarter in 2009 to the 1st quarter in 2010. METHODS We collected 2 106 sera for 4 age groups in 6 consecutive months. Hemagglutination inhibition tests were used to determine the level of antibody for H1N1 virus. RESULTS 2 106 persons were included in this investigation. The total positive rate was 18.14%; 17.00% and 19.48% for males and females, respectively. There were significant differences of antibody levels across collecting time periods, age groups and H1N1 vaccine history （P 〈 0.05）. CONCLUSION The aver- age proportions of antibody for H1N1 virus in general population in Wuhan during the 4th quarter in 2009 to the 1st with quarter in 2010 were above 18%, which is still low. Compared with people do not receive vaccination, people received H1N1 vaccina- tion have significantly increased levels of antibody, which indicates the protective effect of H1N1 vaccine.

关 键 词：甲型H1N1流感 抗体水平 普通人群 

分 类 号：R373.13[医药卫生—病原生物学]