米非司酮、米索前列醇与清宫术三联治疗稽留流产64例临床观察  

Clinical observation of 64 cases of missed abortion treated by triple therapy of mifepristone, misoprostol and uterine curettage

作　　者：黄文[1] 朱晓燕[1] 刘爱兴[1] 

机构地区：[1]广东省东莞市人民医院妇产科,广东东莞523000

出　　处：《中国当代医药》2013年第3期52-53,共2页China Modern Medicine

摘　　要：目的探讨米非司酮、米索前列醇与清宫术联合应用于稽留流产治疗的临床效果。方法选取本院2010年6月～2011年6月收治稽留流产患者128例,采用随机数字表法分为对照组和联合治疗组,每组64例,分别采用乙烯雌醇+清宫术和米非司酮+米索前列醇+清宫术治疗;比较两组患者手术时间、术中出血量、一次清宫成功率,镇痛及宫颈软化、扩张总有效率,人工流产综合征发生率等。结果联合治疗组患者手术时间及术中出血量均明显少于对照组(P<0.05);联合治疗组患者一次清宫成功率明显高于对照组(P<0.05);联合治疗组患者镇痛总有效率明显高于对照组(P<0.05);联合治疗组患者宫颈软化、扩张总有效率明显高于对照组(P<0.05);同时联合治疗组患者人工流产综合症发生率明显低于对照组(P<0.05)。结论米非司酮、米索前列醇联合清宫术三联治疗稽留流产能够减少术中创伤、提高镇痛效果及一次清宫成功率,降低不良反应发生风险。Objective To investigate the effects of triple therapy of mifepristone, misoprostol and uterine curettage in treatment of missed abortion. Methods One hundred and twenty-eight cases of missed abortion patients who were treated in our hospital from June 2010 to June 201 l were randomly divided into control group and treatment group with 64 cases in each group by the method of random number table, the control group was treated by orgabolin and u- terine curettage, the treatment group was treated by mifepristone plus misoprostol plus uterine curettage. The operation time, intraoperative bleeding amount, one-time success rate, the total effective rate of analgesia, cervical softening and expanding, the occurrence of induced abortion syndrome and so on of two groups were compared. Results The opera- tion time and intraoperative bleeding amount of the treatment group patients were significantly less than that in control group （P 〈 0.05）, the one-time success rate and the total effective rate of analgesia, cervical softening and expanding of the treatment group patients was obvious higher than that in control group （P 〈 0.05）. At the same time, the occurrence of induced abortion syndrome of the treatment group patients was significantly lower than that of the control group （P 〈 0.05）. Conclusion Triple therapy of mifepristone, misoprostol and uterine curettage in the treatment of missed abortion can reduce intraoperative trauma, improve analgesia effect and one-time success rate, and reduce the risk of adverse reaction.

关 键 词：米非司酮 米索前列醇 清宫术 稽留流产 疗效 安全性 

分 类 号：R71[医药卫生—妇产科学]