219例抗菌药物不良反应分析  

The adverse drug reaction analysis of 219 cases of antibiotics

作　　者：潘建华[1] 韩莹旻[1] 何晶[1] 

机构地区：[1]大连大学附属中山医院药剂科,辽宁大连116001

出　　处：《中国当代医药》2013年第4期152-153,共2页China Modern Medicine

摘　　要：目的分析本院219例抗菌药物不良反应报告的相关因素,为临床安全、有效、合理用药提供参考。方法对2008年10月～2012年9月本院临床科室上报的219例抗菌药物不良反应进行回顾性分析。结果 219例抗菌药物不良反应报告中涉及药物有青霉素类、头孢菌素类、大环内酯类、喹诺酮类等9大类,25个品种;青霉素类引起的不良反应最多,共75例,占34.25%,其次为喹诺酮类,共72例,占32.88%;静脉给药方式为引起不良反应最主要的途径;主要不良反应累及系统/器官为皮肤及附件损害,共83例,占37.90%,其次为消化系统损害,37例,占16.89%。结论必须合理使用抗菌药物,加强临床用药过程中的监测,以避免或减少不良反应的发生。Objective To analyze the relatdd factors of 219 adverse drug reactions （ADRs） of antibiotics in our hospital, aiming to provide safe, effective and rational drug use for clinic. Methods Two hundred and nineteen cases of 219 ADRs reported by clinical departments in our hospital from Oct. 2008 to Sep. 2012 were analyzed retrospectively. Re- suits There were 9 categories of drugs involved in all the ADRs included penicillin, cephalosporin, large ring lactones and quinolones an altogether 25 kinds in the 219 ADRs of antibiotics. There were 75 ADRs caused by penicillin, which ranked the first and occupied 34.25% of the total. Then followed quinolones, with 72 reports and occupied 32.88%. The major pathway that caused ADRs was intravenous administration. There were 83 ADRs involving injuries of skin and accessories, which occupied 37.90%. 37 ADRs involved digestive system injuries, which occupied 16.89%. Conclusion In order to avoid and minimize ADRs, we must use antibiotics rationally and enforce monitoring of clinical medication.

关 键 词：抗菌药物 不良反应 分析 合理用药 

分 类 号：R969.3[医药卫生—药理学]