巴戟天醇提物对D-半乳糖致衰老大鼠免疫功能的影响  

Effects of radix Morindae officinalis ethanolic extracts on immune function in rats induced by D-galactose

作　　者：王雪侠[1,2] 张向前 

机构地区：[1]郑州大学基础医学院,河南郑州450000 [2]郑州市妇幼保健院检验科,河南郑州450000 [3]河南电力医院检验科,河南郑州450000

出　　处：《中国医药导报》2013年第4期17-19,共3页China Medical Herald

摘　　要：目的探讨巴戟天醇提物对D-半乳糖致衰老大鼠免疫功能的影响。方法 50只健康雄性Wistar大鼠随机均分为空白对照组、模型对照组、维生素E组、巴戟天高剂量组和巴戟天低剂量组,每组各10只。利用D-半乳糖制作衰老大鼠模型,并用维生素E及两种不同剂量的巴戟天醇提物进行灌胃。给药结束后,检测大鼠的胸腺指数、脾脏指数、T淋巴细胞转化指数、B淋巴细胞转化指数、白介素-2(IL-2)水平以及CD28阳性淋巴细胞数。结果与模型对照组比较,维生素E组、巴戟天高剂量组和巴戟天低剂量组胸腺指数、脾脏指数、T淋巴细胞转化指数、B淋巴细胞转化指数、IL-2水平以及CD28阳性淋巴细胞数明显升高,差异均有统计学意义(均P<0.05)。结论巴戟天醇提物能够增强D-半乳糖致衰老大鼠的免疫功能,可能具有延缓衰老的作用。Objective To investigate the effects of radix Morindae officinalis ethanolic extracts on immune function in rats induced by D-galactosel Methods 50 healthy male Wistar rats were randomly divided into 5 groups： the blank control group, the model group, the vitamin E group, the radix Morindae officinalis high dose group and the radix Morindae officinalis low dose group with 10 rats in each group. The aged rats were induced by D-galactose, and rats in all the administration groups were respectively given Vitamin E, high dose or low dose of radix Morindae officinalis. The thymus gland index, spleen index, T lymphocyte stimulation index, B lymphocyte Stimulation index, level of inter- leukin-2 （IL-2）, cell amount with positive CD28 were detected in all the 5 groups. Results Compared with the model group, the thymus gland index, spleen index, T lymphocyte stimulation index, B lymphocyte stimulation index, level of IL-2, cell amount with positive CD28 were all higher in the vitamin E group, the radix Morindae officinalis high dose group and the radix Morindae officinalis tow dose group, the differences were all statistically significant （all P 〈 0.05）. Conclusion Radix Morindae officinalis ethanolic extracts can enhance the immune function of rats induced by D- galactose, and it can delay the aged.

关 键 词：巴戟天醇提物 D-半乳糖 免疫功能 刺激指数 白介素-2 CD28 

分 类 号：R393[医药卫生—基础医学]