层层自组装膜的研究:从基础到生物医学领域中的应用  

Layer-by-layer Assembled Films:from Fundermentals to Biomedical Applications

作　　者：关英[1] 张拥军[1] 张文静 张曦 丁智博[1] 朱晓夏[1,2] 

机构地区：[1]功能高分子材料教育部重点实验室,南开大学化学学院高分子化学研究所,天津300071 [2]蒙特利尔大学化学系

出　　处：《高分子通报》2013年第1期40-52,共13页Polymer Bulletin

基　　金：国家自然科学基金(Nos.20974049;21274068;21228401);科技部国际科技合作项目(No.2007DFA50760)资助

摘　　要：层层自组装是利用分子间的静电、氢键、共价键等相互作用将高分子组装成膜的技术,具有操作简单、无需特殊设备、膜组分及厚度可控等优点,在器件制备、表面改性及生物医学等诸多领域有广泛应用。我们在层层自组装膜的基础研究及应用领域均进行了一些探索,首次将氢键和共价键层层组装技术从二维体系扩展到三维体系,成功地制备了氢键和共价键键合的层层组装的空心微胶囊;提出了制备单一组分层层自组装膜的通用办法;对以聚乙烯基吡喏烷酮/聚丙烯酸膜为代表的氢键自组装膜进行了详细研究。首次以可逆共价键-苯硼酸酯键为驱动力进行层层组装,并在这些研究的基础上提出了动态层层自组装膜的概念。利用动态膜逐步解离的特性提出了新的药物释放方法,同时,利用层层自组装水凝胶膜的刺激响应性还提出了新的可快速响应的光学传感方法。Layer-by-layer （LbL） assembly is a method for the fabrication of polymer films exploiting the interactions between a pair of polymers, such as electrostatic interaction, hydrogen bonding, and covalent bonding. Since it is simple, requires no special instruments, and has a fine control of the film composition and thickness, it has found applications in the fabrication of devices, surface modification and various biomedical fields. Our efforts in this area include both fundenmental issues and biomedical applications. We first extended the LhL methods based on hydrogen bonding and covalent bonding from 2D systems to 3D systems and fabricated hollow capsules based on hydrogen bonds and covalent bonds. We proposed a general method for the fabrication of single component LbL films and capsules. Using poly（vinylpyrrolidone）/polyacrylic acid film as example, we studied the hydrogen-bonded LbL films extensively. We also first fabricated LbL films using the reversible covalent bond （i. e. , phenyl boronate ester bond） as the driving force. Based on these experiments, we recently proposed the conception of dynamic layer-by-layer assembled films. A new drug delivery method has been proposed which exploits the gradual disintegration of dynamic LbL films. We also proposed a new fast-responding optical sensing method based on stimuli-responsive hydrogel films fabricated via LbL assembly.

关 键 词：层层自组装 药物控释 生物传感 

分 类 号：TQ460.1[化学工程—制药化工] TB383.2[一般工业技术—材料科学与工程]