利伐沙班预防髋关节周围骨折手术后深静脉血栓形成的疗效  

Efficacy of rivaroxaban on preventing deep vein thrombosis in postoperative hip joint peripheral bone fracture

作　　者：苗向丽[1] 

机构地区：[1]大同煤矿集团有限责任公司二医院骨科,山西大同037031

出　　处：《中国实用医刊》2013年第3期23-24,共2页Chinese Journal of Practical Medicine

摘　　要：目的观察利伐沙班对于髋关节周围骨折手术后预防深静脉血栓形成的疗效和安全性。方法选择我院自2009年9月至2011年9月行髋关节周围骨折手术治疗的患者100例，随机将其分成利伐沙班组和低分子肝素钠组，每组各50例。利伐沙班组给予利伐沙班片10mg／d口服，从手术后6h后开始，持续用药14d；低分子肝素钠组给予低分子肝素钠40mg／d皮下注射，从手术后24h内开始，持续用药14d。于术后14d对两组患者进行双下肢静脉彩色多普勒超声检查，比较两组深静脉血栓形成情况。结果低分子肝素钠组发生深静脉血栓8例（16．00％）；利伐沙班组发生深静脉血栓2例（4．00％），两组比较差异具有统计学意义（P〈0．05）。利伐沙班组无明显不良反应发生。结论利伐沙班能有效地预防髋关节周围骨折手术后深静脉血栓形成，具有良好的疗效和安全性。Objective To investigate the clinical efficacy of rivaroxaban on preventing deep vein thrombosis （DVT） in postoperative bone fractures around hip joint. Methods One hundred patients with hip joint peripheral bone fracture treated by operation in our hospital from September 2009 to September 2011, they were selected and randomly divided into two groups, rivaroxaban and low molecular weight heparin （LMWH） groups, 50 cases in each group. The rivaroxaban group was given oral rivaroxaban 10 mg at postoperative 6 hours, once a day for continuous 14 days. The LMWH group was given LMWH 40 mg/d within postoperative 24 hours, by subcutaneous injection for continuous 14 days. Fourteen days after treatment, color doppler ultrasound examination was performed, compared the deep veins of lower extremities between the two groups. Results Eight case had DVT in the LMWH group with the occurrence rate of 16% and two cases had DVT in the rivaroxaban group with the occurrence rate of 4% , showing statistical difference between the two groups （ P 〈 0.05 ） . The rivaroxaban group had no obvious adverse reaction. Conclusions Rivaroxaban can effectively prevent postoperative DVT in hip joint peripheral bone fracture and has good effect with less adverse reaction.

关 键 词：利伐沙班 低分子肝素 髋关节周围骨折 预防 深静脉血栓 

分 类 号：R687[医药卫生—骨科学] R54[医药卫生—外科学]