二甲双胍对体外受精中PCOS妇女治疗有效性的系统性评价  

Effectiveness of Treatment with Metformin in Women with Polycystic Ovary Syndrome Undergoing IVF:A Systematic Review and Meta-analysis

作　　者：肖劲松[1] 陈双郧[2] 张春莲[2] 常双[3] 

机构地区：[1]湖北医药学院附属太和医院生殖中心,湖北省十堰市442000 [2]湖北医药学院附属太和医院妇产科,湖北省十堰市442000 [3]湖北医药学院附属太和医院肿瘤科,湖北省十堰市442000

出　　处：《国际生殖健康／计划生育杂志》2013年第1期20-25,共6页Journal of International Reproductive Health/Family Planning

摘　　要：目的:系统性评价二甲双胍对体外受精(IVF)中多囊卵巢综合征(PCOS)患者治疗的有效性。方法:计算机检索中国生物医学文献数据库(CBMdisc)、万方医学网、中国期刊全文数据库(CNKI)、中国生物医学期刊数据库(维普);PubMed、ProQust Medical Libraray(PML)、《外文生物医学期刊文献数据库》(英文缩写FMJS)、读秀学术搜索(www.duxiu.com),并手工检索相关杂志9种,检索时间从各刊建刊至2011年12月底。纳入二甲双胍对IVF中PCOS妇女治疗的随机对照试验(RCT),质量评价后进行Meta分析。结果:共纳入6篇RCT,共计607例患者。Meta分析结果显示,与安慰剂组(对照组)比较,二甲双胍组人绒毛膜促性腺激素(hCG)日雌二醇(E2)值、卵巢过度刺激综合征(OHSS)发生率、周期取消率较低,妊娠率较高,2组差异有统计学意义(P<0.05);2组刺激时间、促性腺激素(Gn)总量、获卵数、流产率和活产率差异无统计学意义(P>0.05)。结论:二甲双胍能显著提高行IVF的PCOS患者的妊娠率,并可以减低OHSS的风险。Objective：To evaluate of the effectiveness of treatment with metformin in PCOS patients undergoing IVF. Methods ： CBM disc, Wan Fang, CNKI, VIP, PubMed, PML, FMJS, Duxiu scholar search （www. duxiu.com） and 9 related journals were searched for the randomized controlled trails （RCTs） on the metformin treatment in PCOS patients undergoing IVF. The search time was from the first published to the end of December,2011. Meta-analysis was performed after quality assessment. Results：Six published studies with 607 patients were included. Meta-analysis showed that E2 value on the hCG day,OHSS rate,and cancellation rate of the metformin group were significantly lower than those of the control group,whereas pregnancy rate of the metformin group was significantly higher （P〈0.05）. No significant differences were found in the stimulation period （days）,total amount of gonadotropin, number of oocytes retrieved,miscarrage rate,and live birth rate between the metformin group and the placebo group. Conclusions：Treatment with metformin can significantly increase pregnancy rate,and reduce risk of OHSS ,in PCOS patients undergoing IVF.

关 键 词：二甲双胍 多囊卵巢综合征 受精 体外 Meta分析 系统性评价 

分 类 号：R711.75[医药卫生—妇产科学]