高血压病患者不同中医证型与血浆同型半胱氨酸水平相关性研究  

Study on Relationship between TCM Syndrome Types and Plasma Homocyste in Patients with Essential Hypertension

作　　者：夏文进[1] 吴敏[1] 王洪[1] 徐鹏[1] 董浙清[1] 肖英俊[1] 徐宇杰[1] 

机构地区：[1]浙江中医药大学附属第三医院,浙江杭州310005

出　　处：《中华中医药学刊》2013年第1期164-166,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江中医药大学科研基金资助项目(2009LX11)

摘　　要：目的:探讨血浆同型半胱氨酸(Hcy)水平与高血压病(EH)中医证型的关系。方法:将200例患者按中医辨证分为肝火亢盛、痰湿壅盛、阴虚阳亢、阴阳两虚4型,用循环酶法检测EH患者与健康对照组血浆Hcy水平。结果:EH患者血浆Hcy水平显著高于健康对照组(P<0.01),EH患者各中医证型血浆Hcy水平均显著高于键康对照组(P<0.01)。肝火亢盛型、痰湿壅盛型血浆Hcy水平显著高于、阴虚阳亢型及气虚痰浊型P<0.01)。结论:血浆Hcy水平异常增高是EH的重要危险因素之一,EH患者血浆HCY水平显著增高可作为中医证型肝火亢盛型、痰湿壅盛型的辨证指标。Objective：To evaluate the relation between serum homocysteine（Hcy） and TCM syndrome types in essential hypertension（EH） patients.Methods：200 cases of essential hypertension were divided into the following 4 syndromes; hyperactivity of liver-fire syndrome,hyperactivity of dampness and phlegm retetion syndrome,yin deficiency and yang excess sydnrome,deficiency of both yin and yang syndrome.Serum homocysteine in patients of EH and the normal control group were detected by enzymatic cycling method.Results：Hcy level in patients of EH was significantly higher than that of healthy controls（P0.01）.Hcy level in the hypertensive patients with different syndromes of TCM was significantly higher than that of healthy controls（P0.01）.Hcy level in the hypertensive patients with liver-fire syndrome,dampness and phlegm retetion syndrome was significandy higher than that of yin deficiency and yang excess syndrome and deficiency of both yin and yang syndrome（P0.01）.Conclusion：Abnormal increase of serum Hcy level is an important risk factor of EH.The significant increase of plasma Hcy level is a Chinese medical pattern identification index of the patients with liver-fire syndrome dampness and phlegm retetion syndrome.

关 键 词：同型半胱氨酸 高血压病 中医证型 

分 类 号：R544.1[医药卫生—心血管疾病]