盐酸阿霉素在纳米载体氧化石墨烯上的可控负载与释放  

Graphene oxide as a nanocarrier for controlled loading and release of doxorubicin hydrochloride

作　　者：李晓[1] 赵东林[1] 白利忠[1] 李峰[1] 赵海静[1] 高龙飞[1] 

机构地区：[1]北京化工大学化工资源有效利用国家重点实验室,碳纤维及功能高分子教育部重点实验室,北京100029

出　　处：《功能材料》2013年第1期96-98,102,共4页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(50672004);国家高技术研究发展计划(863计划)资助项目(2008AA03Z513)

摘　　要：采用改性Hummers法制备了氧化石墨烯,并探索了其在生物医学方面作为纳米药物载体的应用。通过超声、振荡等方法制备了氧化石墨烯-盐酸阿霉素(GO-DXR),采用高分辨透射电镜(HRTEM)、傅里叶变换红外光谱(FT-IR)、紫外-可见分光光谱(UV-Vis)等测试方法对GO负载DXR前后的形貌和结构进行了研究。DXR在GO上的负载量高达4.6mg/mg,DXR的释放量可通过pH值控制,说明GO与DXR之间依靠氢键作用结合。We synthesize nano-graphene oxide with modified hummers and explore the biological applications of nano-graphene oxide as a nanocarrier.A novel graphene oxide-doxorubicin hydrochloride was prepared via a method of sonication and oscillation,the loading and release behaviors of DXR on GO were investigated by high-resolution transmission electron microscopy（HRTEM）,Fourier transform infrared spectroscopy and UV-Vis spectrophotometer.The loading capacity was up to 4.6mg/mg,the release of DXR indicated strong pH dependence and imply hydrogen-bonding interaction between GO and DXR.

关 键 词：氧化石墨烯 盐酸阿霉素 纳米药物载体 药物释放 

分 类 号：TQ127.1[化学工程—无机化工] R917[医药卫生—药物分析学]