西藏大骨节病区藏族居民血清指标检测分析  

Correlations between diet structure and serum indicators among population in Kashin-Beck disease area in Tibet

作　　者：次央[1] 央宗[1] 巴桑卓玛[1] 西绕若登[2] 白玛次旺[2] 赵生成[2] 扎西桑珠[2] 

机构地区：[1]西藏大学医学院预防医学系,西藏拉萨850002 [2]西藏自治区疾病预防控制中心地方病防制研究所

出　　处：《中国公共卫生》2013年第1期122-125,共4页Chinese Journal of Public Health

基　　金：国家自然科学基金(30660165)

摘　　要：目的测定西藏大骨节病病区人群血清总蛋白(TP)、总胆固醇(TC)、钙、锌和硒的含量,分析其与当地膳食结构之间的关系。方法采集西藏大骨节病病区人群580份血液样本,测定上述5项血清指标的含量,并分析与当地膳食结构的相关性。结果病区人群血清中TC、锌、硒的含量低于正常值,尤其是血清硒含量[(26.87±28.30)μg/L]低于正常值的50%;大骨节病患者血清硒含量[(17.52±14.54)μg/L)]远低于非患者血清硒含量[(30.47±31.34)μg/L](t=5.035,P<0.001);病区内只食用当地糌粑的人群血清硒含量[(18.66±19.64)μg/L]低于食用≥2种主食的人群血清硒含量[(33.23±32.12)μg/L](t=-6.354,P<0.001);病区人群中肉、蛋、奶、蔬菜的摄入频率与人群血清中TP、TC、钙、锌、硒的含量相关。结论西藏大骨节病病区除环境低硒的致病因素外,由于膳食结构不合理导致人群营养状况较差,可能也是大骨节病易发的重要因素。Objective To determine serum total protein（TP）,total cholesterol（TG）,calcium（Ca）,zinc（Zn） and selenium（Sc） in a population from Kashin-Beck disease area in Tibet and to evaluate the relationship between the occurrence of Kashin-Beck disease and nutrition status.Methods Blood samples were collected from the population in Kashin-Beck disease area and detected for seurm TP,TG,Ca,Zn,and Se.The correlation analysis for the prevalence of Kashin-Beck disease and nutrition status was conducted.Results Serum TG,Zn,and Se levels in the population were lower than the normal,especially for Se level（26.87±28.30 μg/L,being less than 50% of normal level）.The Se level was lower among the people with Kashin-Beck disease（17.52±14.54 μg/L） compared to the people without Kashin-Beck disease（30.47±31.34 μg/L）（t=5.035,P0.001）.The Se level was significantly lower in the people only consumming local tsampa（18.66±19.64 μg/L）compared to the people consuming at least two staple foods（33.23±32.12 μg/L）（t=-6.354,P0.001）.The frequencies of meat,eggs,milk,and vegetable consumption were related to TP,TG,Ca,Zn,and Se.Conclusion Except for the deficiency of Se in the environment,other pathogenic factors for Kashin-Beck disease exist in Tibet.The poor nutrition status in the population due to unreasonable diet structures might be an important risk factor for the occurrence of Kashin-Beck disease.

关 键 词：西藏 大骨节病 血清总蛋白(TP) 血清总胆固醇(TC) 血清钙 血清锌 血清硒 

分 类 号：R599[医药卫生—内科学]