药物源性肾损伤发生机制的研究进展  

Mechanism of Drug-induced Renal Injury

作　　者：于敏[1] 张双庆[1] 李佐刚[1] 

机构地区：[1]中国食品药品检定研究院食品药品安全评价研究所,北京100176

出　　处：《中国药事》2012年第12期1388-1392,共5页Chinese Pharmaceutical Affairs

摘　　要：目的综述药物诱发的急性肾功能损伤的发生机制。方法参考国内外文献,对免疫介导的损伤、细胞氧化损伤、细胞钙稳态紊乱等细胞毒性进行分类、归纳整理。结果大多数肾小球损伤由免疫介导的损伤引起,原发性肾小管-间质性损伤主要由药物、重金属等细胞毒性作用引起。结论药物源性肾损伤机制包括药物致肾小球滤过功能障碍和药物致肾小管功能障碍。Objective To review the genesis mechanism of drug-induced renal injury.Methods By reviewing the literature,the cytotoxicity of immune mediated injury,oxidative cell injury and abnormal intracellular calcium homeostasis was categorized and analyzed.Results The glomerular damage is mainly caused by immune reaction,and primary renal tubular-interstitial damage is mainly caused by cytotoxicity of drug,heavy metals and so on.Conclusion The mechanism of drug-induced renal injury includes glomerular filtration dysfunction and renal tubular dysfunction.

关 键 词：肾毒性 免疫损伤 自由基 细胞毒性 钙稳态 

分 类 号：R96[医药卫生—药理学]